Mohamed Reda Keddar

AstraZeneca (United Kingdom) — United Kingdom

Medicine · Health Sciences

9h-index621citations42works33.32yr avg
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Research Topics

Cancer Immunotherapy and Biomarkers(17), Bioinformatics and Genomic Networks(12), Cancer Genomics and Diagnostics(12), Immune Cell Function and Interaction(9), Single-cell and spatial transcriptomics(7)

Publications42 total

Abstract PS1-11-08: Integrative modeling of multimodal real-world data for improved risk stratification of first-line CDK4/6 inhibitor outcomes in patients with estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer
Clinical Cancer Research·2026
KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer
Cancer Cell·2025· 13 citedOpen Access
Tumor microenvironments with an active type I IFN response are sensitive to inhibitors of heme degradation
JCI Insight·2025· 1 citedOpen Access
Pan-cancer analysis in the real-world setting uncovers immunogenomic drivers of acquired resistance post-immunotherapy
2025Open Access
Pan-Cancer Analysis in the Real-World Setting Uncovers Immunogenomic Drivers of Acquired Resistance Post-Immunotherapy
SSRN Electronic Journal·2025Open Access
Abstract 5100: Multimodal real world data reveals immunogenomic drivers of acquired and primary resistance to immune checkpoint blockade
Cancer Research·2024
Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial
Nature Medicine·2024· 104 citedOpen Access
Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
Cancer Cell·2024· 148 citedOpen Access
620 Multimodal real world data reveals immunogenomic drivers of acquired and primary resistance to immune checkpoint blockade
Regular and Young Investigator Award Abstracts·2023Open Access
Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment
Genome Medicine·2023· 9 citedOpen Access
Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment
2023Open Access
Additional file 2 of Mechanistic insights into the interactions between cancer drivers and the tumour immune microenvironment
Figshare·2023Open Access
A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution
Nature Communications·2022· 44 citedOpen Access
Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Genome biology·2022· 112 citedOpen Access
Additional file 6 of Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Figshare·2022Open Access
Additional file 1 of Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Figshare·2022Open Access
Additional file 3 of Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Figshare·2022Open Access
Additional file 4 of Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Figshare·2022Open Access
Additional file 7 of Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Figshare·2022Open Access
Additional file 8 of Comparative assessment of genes driving cancer and somatic evolution in non-cancer tissues: an update of the Network of Cancer Genes (NCG) resource
Figshare·2022Open Access
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Frequent Co-authors

Francesca D. Ciccarelli(31), Michele Bortolomeazzi(27), Lucia Montorsi(26), Amelia Acha‐Sagredo(21), Damjan Temelkovski(16), Manuel Rodriguez‐Justo(16), Jo Spencer(16), Hrvoje Mišetić(13), Lisa Dreßler(10), G Sartini(10), Neshika Wijewardhane(10), Dimitra Repana(10), Joel Nulsen(10), Jacki Goldman(10), Patrick Davis(10), Amy Strange(10), Karen Ambrose(10), Marc Pollitt(9), Michael J. Pitcher(9), Gianluca Basso(9)