Juan I. Garaycoechea

University Medical Center Utrecht — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.9kcitations19works7.52yr avg
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Research Topics

DNA Repair Mechanisms(10), Carcinogens and Genotoxicity Assessment(6), Cancer Genomics and Diagnostics(3), Epigenetics and DNA Methylation(2), Hematopoietic Stem Cell Transplantation(2)

Publications19 total

Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair
Nature Communications·2025· 1 citedOpen Access
p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice
Nature Communications·2024· 14 citedOpen Access
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
Molecular Cell·2023· 36 citedOpen Access
Pathological consequences of DNA damage in the kidney
Nature Reviews Nephrology·2023· 23 cited
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
Nature Genetics·2022· 96 citedOpen Access
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
Nature·2021· 133 citedOpen Access
Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
UNC Libraries·2021Open Access
XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways
PLoS Genetics·2020· 21 citedOpen Access
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells
Nature·2018· 399 citedOpen Access
Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
Molecular Cell·2015· 385 citedOpen Access
Do Mutational Dynamics in Stem Cells Explain the Origin of Common Cancers?
Cell stem cell·2015· 7 citedOpen Access
Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases
Nucleic Acids Research·2014· 48 citedOpen Access
Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
Molecular Cell·2014· 136 citedOpen Access
Why does the bone marrow fail in Fanconi anemia?
Blood·2013· 160 citedOpen Access
A comparative study on phosphotransferase activity of acid phosphatases from Raoultella planticola and Enterobacter aerogenes on nucleosides, sugars, and related compounds
Applied Microbiology and Biotechnology·2013· 17 cited
Aldéhydes et anémie de Fanconi
médecine/sciences·2013· 2 citedOpen Access
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
Nature·2012· 388 cited
Biocatalysed halogenation of nucleobase analogues
Biotechnology Letters·2011· 17 cited
Synthesis of nucleoside and pentose monophosphates by acid phosphatase over-producing whole cells
New Biotechnology·2009

Frequent Co-authors

Ketan J. Patel(10), Gerry P. Crossan(9), Mark J. Arends(4), Frédéric Langevin(3), Lee Mulderrig(3), Rosario Médici(3), Elizabeth S. Lewkowicz(3), Adolfo M. Iribarren(3), Lucas B. Pontel(2), Iván V. Rosado(2), Guillermo Burgos-Barragan(2), G. Chandrasekaran(2), Verena Broecker(2), Limin Liu(2), James A. Swenberg(2), Felix A. Dingler(2), Ana Laura Valino(2), Claudio A. Pereira(2), Sandra Louzada(1), Fengtang Yang(1)