David J. Burkhart

Center for Translational Molecular Medicine — Netherlands

Immunology and Microbiology · Life Sciences

19h-index1.2kcitations91works2.22yr avg
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Research Topics

Immune Response and Inflammation(20), Immunotherapy and Immune Responses(17), Influenza Virus Research Studies(11), Chemical Synthesis and Analysis(8), Crystallization and Solubility Studies(8)

Publications91 total

Covalent conjugation of a TLR7/8 agonist to recombinant influenza A virus hemagglutinin provides enhanced immunogenicity and protection against disease from a drifted strain 9291
The Journal of Immunology·2025Open Access
In silico discovery and mechanistic profiling of STING agonists engaging the transmembrane domain
European Journal of Medicinal Chemistry·2025Open Access
Characterization of a Novel Transmembrane Activating STING Agonist using Genetically Humanized Mice
2025· 1 citedOpen Access
The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine
npj Vaccines·2025· 3 citedOpen Access
Encapsulation of the lipidated TLR7/8 agonist INI-4001 into ionic liposomes impacts H7 influenza antigen-specific immune responses
Drug Delivery and Translational Research·2025Open Access
A novel cationic liposome-formulated toll like receptor (TLR) 7/8 agonist enhances the efficacy of a vaccine against fentanyl toxicity
Journal of Controlled Release·2025· 5 cited
A cationic liposome-formulated Toll Like Receptor (TLR)7/8 agonist enhances the efficacy of a vaccine against fentanyl toxicity
2025· 1 citedOpen Access
In Silico Discovery and Mechanistic Profiling of Sting Agonists Engaging the Transmembrane Domain
SSRN Electronic Journal·2025Open Access
The TLR7/8 agonist INI-4001 enhances the immunogenicity of a Powassan virus-like-particle vaccine
2024· 1 citedOpen Access
Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists
International Journal of Molecular Sciences·2024· 3 citedOpen Access
Vaccination with ancestral SARS-CoV-2 spike adjuvanted with TLR agonists provides cross-protection against XBB.1
npj Viruses·2024· 6 citedOpen Access
Intranasal administration of a synthetic TLR4 agonist INI-2004 significantly reduces allergy symptoms following therapeutic administration in a murine model of allergic sensitization
Frontiers in Immunology·2024· 3 citedOpen Access
Promotion of Th17 Polarized Immunity via Co-Delivery of Mincle Agonist and Tuberculosis Antigen Using Silica Nanoparticles
ACS Applied Bio Materials·2024· 6 cited
Mechanistic insights into the cellular and molecular mechanisms of an anti-opioid vaccine formulated with a novel Toll-Like receptor (TLR) 7/8 agonist
Journal of Pharmacology and Experimental Therapeutics·2024
Toxicology testing in minipigs of a heroin vaccine intended for clinical treatment of opioid use disorder
Journal of Pharmacology and Experimental Therapeutics·2024
Adjuvanted Vaccine Induces Functional Antibodies against Pseudomonas aeruginosa Filamentous Bacteriophages
Vaccines·2024· 1 citedOpen Access
Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses
Pharmaceutics·2024· 7 citedOpen Access
Co-Delivery of Novel Synthetic TLR4 and TLR7/8 Ligands Adsorbed to Aluminum Salts Promotes Th1-Mediated Immunity against Poorly Immunogenic SARS-CoV-2 RBD
Vaccines·2023· 6 citedOpen Access
Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses
Preprints.org·2023· 1 citedOpen Access
Co-delivery of Novel Synthetic TLR4 and TLR7/8 Ligands Adsorbed to Aluminum Salts Promotes Th1-Mediated Immunity against Poorly Immunogenic SARS-CoV-2 RBD
Preprints.org·2023· 4 citedOpen Access
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Frequent Co-authors

Jay T. Evans(26), Shannon M. Miller(10), Hélène G. Bazin(9), Karthik Siram(9), Walid Abdelwahab(9), Stephanie K. Lathrop(8), Clara J. Davison(7), Tad H. Koch(6), Nicholas R. Natale(6), Glen C. Post(5), Lois Walsh(5), Linda D. Hicks(5), Brian T. Kalet(4), Van Cybulski(4), Margaret Whitacre(4), Benjamin L. Barthel(4), Roman Schoener(4), Alyson Smith(4), Cassandra Buhl(4), Kendal Ryter(4)