Hazel M. Holden

University of Wisconsin–Madison — United States

Materials Science · Physical Sciences

74h-index20.0kcitations600works0.82yr avg
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Research Topics

Enzyme Structure and Function(225), Biochemical and Molecular Research(91), Amino Acid Enzymes and Metabolism(68), Metabolism and Genetic Disorders(50), Carbohydrate Chemistry and Synthesis(48)

Publications600 total

A method for facile production of variable lymphocyte receptors using <scp> SHuffle <i>Escherichia coli</i> </scp>
Biotechnology Progress·2025Open Access
The High‐Resolution Structure of a Variable Lymphocyte Receptor From <i>Petromyzon marinus</i> Capable of Binding to the Brain Extracellular Matrix
Proteins Structure Function and Bioinformatics·2024· 2 citedOpen Access
Author response for "The High-Resolution Structure of a Variable Lymphocyte Receptor From &lt;i&gt;Petromyzon marinus&lt;/i&gt; Capable of Binding to the Brain Extracellular Matrix"
2024
Biosynthesis of Cytidine Diphosphate-6-<scp>d</scp>-Glucitol for the Capsular Polysaccharides of <i>Campylobacter jejuni</i>
Biochemistry·2024· 1 citedOpen Access
Structural analysis of a bacterial UDP-sugar 2-epimerase reveals the active site architecture before and after catalysis
Journal of Biological Chemistry·2023Open Access
Characterization of a novel inhibitor for the New Delhi metallo-β-lactamase-4: Implications for drug design and combating bacterial drug resistance
Journal of Biological Chemistry·2023· 8 citedOpen Access
Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides of <i>Campylobacter jejuni</i>
Biochemistry·2022· 9 citedOpen Access
Investigation of the enzymes required for the biosynthesis of 2,<scp>3‐</scp>diacetamido‐2,3‐dideoxy‐<scp>d</scp>‐glucuronic acid in <i>Psychrobacter cryohalolentis</i><scp>K5<sup>T</sup></scp>
Protein Science·2022· 2 citedOpen Access
C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from <i>Campylobacter jejuni</i>
Biochemistry·2022· 13 citedOpen Access
Reaction Mechanism and Three-Dimensional Structure of GDP-<scp>d</scp>-glycero-α-<scp>d</scp>-manno-heptose 4,6-Dehydratase from <i>Campylobacter jejuni</i>
Biochemistry·2022· 9 citedOpen Access
Structure and function of an <i>N</i>‐acetyltransferase from the human pathogen <i>Acinetobacter baumannii</i> isolate BAL_212
Proteins Structure Function and Bioinformatics·2022· 2 citedOpen Access
4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase
ACS Chemical Biology·2021· 17 citedOpen Access
Biochemical investigation of an <scp><i>N</i>‐</scp>acetyltransferase from <scp><i>Helicobacter pullorum</i></scp>
Protein Science·2021· 5 citedOpen Access
Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen <scp><i>Helicobacter canadensis</i></scp>
Protein Science·2021· 6 citedOpen Access
crystal structure of the N-formyltrasferase HCAN_0200 from Helicobacter canadensis on complex with folinic acid and dTDP-3-aminofucose
2021
crystal structure of the dTDP-Qui3N N-formyltransferase from Helicobacter canadensis, apo form
2021
From the Three-Dimensional Structure of Phosphotriesterase
Biochemistry·2021· 9 cited
Characterization of an aminotransferase from <scp><i>Acanthamoeba polyphaga</i></scp><i>Mimivirus</i>
Protein Science·2021· 3 citedOpen Access
Biosynthesis of <scp>d</scp>-<i>glycero</i>-<scp>l</scp>-<i>gluco</i>-Heptose in the Capsular Polysaccharides of <i>Campylobacter jejuni</i>
Biochemistry·2021· 19 citedOpen Access
X-ray structure of the L136 Aminotransferase from Acanthamoeba polyphaga mimivirus in the presence of TDP and PMP
2021
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Frequent Co-authors

James B. Thoden(18), Ivan Rayment(17), Matthew M. Benning(11), Frank M. Raushel(11), G.E. Wesenberg(8), W. Rypniewski(4), Perry A. Frey(4), Pamela J. Shaw(3), Paul R. Heath(3), Sheila Francis(3), Grover L. Waldrop(3), Robert W. Smith(2), Kenneth C. Holmes(2), Gordon W. Duff(2), Cathy M. Holt(2), John H. Law(2), Jane M. Kuo(2), Todd M. Larsen(2), Dale E. Tronrud(2), Brian W. Matthews(2)