Xiaosai Ruan

Kansas State University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index625citations16works0.02yr avg
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Research Topics

Escherichia coli research studies(15), Viral gastroenteritis research and epidemiology(13), Clostridium difficile and Clostridium perfringens research(9), Antibiotic Resistance in Bacteria(2), Veterinary medicine and infectious diseases(2)

Publications16 total

Preclinical Characterization of Immunogenicity and Efficacy against Diarrhea from MecVax, a Multivalent Enterotoxigenic E. coli Vaccine Candidate
Infection and Immunity·2021· 34 citedOpen Access
Erratum to “Antibodies derived from a toxoid MEFA (multiepitope fusion antigen) show neutralizing activities against heat-labile toxin (LT), heat-stable toxins (STa, STb), and Shiga toxin 2e (Stx2e) of porcine enterotoxigenic Escherichia coli (ETEC)” [Vet. Microbiol. 202 (2017) 79–89]
Veterinary Microbiology·2018Open Access
Enterotoxigenic Escherichia coli Adhesin-Toxoid Multiepitope Fusion Antigen CFA/I/II/IV-3xSTa <sub>N12S</sub> -mnLT <sub>G192G/L211A</sub> -Derived Antibodies Inhibit Adherence of Seven Adhesins, Neutralize Enterotoxicity of LT and STa Toxins, and Protect Piglets against Diarrhea
Infection and Immunity·2017· 26 citedOpen Access
Enterotoxigenic<i>Escherichia coli</i>heat-stable toxin and heat-labile toxin toxoid fusion 3xSTaN12S-dmLT induces neutralizing anti-STa antibodies in subcutaneously immunized mice
FEMS Microbiology Letters·2016· 48 citedOpen Access
Antibodies derived from an enterotoxigenic Escherichia coli (ETEC) adhesin tip MEFA (multiepitope fusion antigen) against adherence of nine ETEC adhesins: CFA/I, CS1, CS2, CS3, CS4, CS5, CS6, CS21 and EtpA
Vaccine·2016· 40 citedOpen Access
Antibodies derived from a toxoid MEFA (multiepitope fusion antigen) show neutralizing activities against heat-labile toxin (LT), heat-stable toxins (STa, STb), and Shiga toxin 2e (Stx2e) of porcine enterotoxigenic Escherichia coli (ETEC)
Veterinary Microbiology·2016· 39 citedOpen Access
Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity
PLoS ONE·2015· 58 citedOpen Access
Characterization of Heat-Stable (STa) Toxoids of Enterotoxigenic Escherichia coli Fused to Double Mutant Heat-Labile Toxin Peptide in Inducing Neutralizing Anti-STa Antibodies
Infection and Immunity·2014· 56 citedOpen Access
Multiepitope Fusion Antigen Induces Broadly Protective Antibodies That Prevent Adherence of Escherichia coli Strains Expressing Colonization Factor Antigen I (CFA/I), CFA/II, and CFA/IV
Clinical and Vaccine Immunology·2013· 47 citedOpen Access
A Multiepitope Fusion Antigen Elicits Neutralizing Antibodies against Enterotoxigenic Escherichia coli and Homologous Bovine Viral Diarrhea Virus<i>In Vitro</i>
Clinical and Vaccine Immunology·2013· 14 citedOpen Access
Oral immunization of a live attenuated Escherichia coli strain expressing a holotoxin-structured adhesin–toxoid fusion (1FaeG-FedF-LTA2:5LTB) protected young pigs against enterotoxigenic E. coli (ETEC) infection
Vaccine·2013· 29 cited
Flagella from F18+ Escherichia coli play a role in adhesion to pig epithelial cell lines
Microbial Pathogenesis·2012· 53 cited
Escherichia coli Expressing EAST1 Toxin Did Not Cause an Increase of cAMP or cGMP Levels in Cells, and No Diarrhea in 5-Day Old Gnotobiotic Pigs
PLoS ONE·2012· 28 citedOpen Access
The flagella of F18ab Escherichia coli is a virulence factor that contributes to infection in a IPEC-J2 cell model in vitro
Veterinary Microbiology·2012· 59 cited
A Tripartite Fusion, FaeG-FedF-LT<sub>192</sub>A2:B, of Enterotoxigenic Escherichia coli (ETEC) Elicits Antibodies That Neutralize Cholera Toxin, Inhibit Adherence of K88 (F4) and F18 Fimbriae, and Protect Pigs against K88ac/Heat-Labile Toxin Infection
Clinical and Vaccine Immunology·2011· 42 citedOpen Access
Heat-Labile- and Heat-Stable-Toxoid Fusions (LT <sub>R192G</sub> -STa <sub>P13F</sub> ) of Human Enterotoxigenic Escherichia coli Elicit Neutralizing Antitoxin Antibodies
Infection and Immunity·2011· 52 citedOpen Access

Frequent Co-authors

Weiping Zhang(16), Qiangde Duan(8), David A. Sack(5), Rahul Nandre(5), D C Robertson(3), David Knudsen(3), Thomas A. Casey(3), Emad A. Hashish(3), Mingxu Zhou(2), Xiaofang Zhu(2), Wenbin Bao(2), Shenglong Wu(2), Jun Zhu(2), Guoqiang Zhu(2), James P. Nataro(2), Mei Liu(2), Chengxian Zhang(2), Dana Rausch(2), Yang Yang(1), John D. Clements(1)