Jason W. Szewczyk

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.4kcitations29works0.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(11), Chemical Synthesis and Analysis(9), RNA and protein synthesis mechanisms(7), Advanced biosensing and bioanalysis techniques(5), Receptor Mechanisms and Signaling(5)

Publications29 total

Discovery of phenyl acetamides as potent and selective GPR119 agonists
Bioorganic & Medicinal Chemistry Letters·2017· 12 citedOpen Access
ChemInform Abstract: Design of Potent and Selective GPR119 Agonists for Type II Diabetes.
ChemInform·2012Open Access
Chapter 7. Recent Advances in the Discovery of GPR119 Agonists
RSC drug discovery/RSC drug discovery series·2012· 6 cited
Design of potent and selective GPR119 agonists for type II diabetes
Bioorganic & Medicinal Chemistry Letters·2010· 31 citedOpen Access
SAR Studies: Designing Potent and Selective LXR Agonists.
ChemInform·2006
Design of ligands for sequence-specific recognition of the minor-major grooves of DNA
CaltechTHESIS (California Institute of Technology)·2006Open Access
SAR studies: Designing potent and selective LXR agonists
Bioorganic & Medicinal Chemistry Letters·2006· 15 citedOpen Access
Nuclear Hormone Receptor Modulators for the Treatment of Diabetes and Dyslipidemia
Annual reports in medicinal chemistry·2006· 21 cited
Combinatorial Libraries for Drug Development
ChemInform·2005
Identification of novel metabolites of pioglitazone in rat and dog
Xenobiotica·2003· 39 cited
Inhibition of major groove DNA binding bZIP proteins by positive patch polyamides
Bioorganic & Medicinal Chemistry·2001· 21 cited
A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C−H Activation
Angewandte Chemie International Edition·2001· 2 cited
A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C-H Activation This work was supported by the Director, Office of Energy Research, Office of Basic Energy Sciences, Chemical Sciences Division, U.S. Department of Energy, under contract No. DE-AC03-76SF00098. We are grateful to the National Institutes of Health for support (GM-50353) and for a Postdoctoral Fellowship to J.W.S.
PubMed·2001· 59 cited
A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C−H Activation
Angewandte Chemie·2001· 20 cited
Untitled
Angewandte Chemie·2001
A Mass Spectrometric Labeling Strategy for High-Throughput Reaction Evaluation and Optimization: Exploring C−H Activation
Angewandte Chemie International Edition·2001· 69 cited
Alternative heterocycles for DNA recognition
Bioorganic & Medicinal Chemistry·2001· 32 cited
Combinatorial Libraries for Drug Development
2000· 1 cited
Recognition of the DNA minor groove by pyrrole-imidazole polyamides: comparison of desmethyl- and N-methylpyrrole
Bioorganic & Medicinal Chemistry·2000· 24 cited
Structural effects of DNA sequence on T·A recognition by hydroxypyrrole/pyrrole pairs in the minor groove 1 1Edited by I. Tinoco
Journal of Molecular Biology·2000· 65 cited
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Frequent Co-authors

Peter B. Dervan(11), Eldon E. Baird(10), Jonathan A. Ellman(7), S.W. White(5), Rebecca L. Zuckerman(5), James M. Turner(4), Robert G. Bergman(4), Ryan Bremer(3), Alan D. Adams(3), Harold B. Wood(3), Clara L. Kielkopf(2), Douglas C. Rees(2), Gary G. Chicchi(2), Peter T. Meinke(2), Shaei Huang(2), Jayne Chin(2), Jenny Tian(2), Lyndon J. Mitnaul(2), Raymond Rosa(2), Larry Peterson(2)