William P. Tansey

Vanderbilt University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index8.5kcitations174works2.22yr avg
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Research Topics

Ubiquitin and proteasome pathways(53), Protein Degradation and Inhibitors(43), Genomics and Chromatin Dynamics(34), Cancer-related gene regulation(28), Signaling Pathways in Disease(26)

Publications174 total

MYC Regulates a DNA Repair Gene Expression Program in Small Cell Carcinoma of the Ovary, Hypercalcemic Type
Cancers·2025Open Access
Ribosome-directed cancer therapies: the tip of the iceberg?
Trends in Pharmacological Sciences·2025· 3 cited
eNRSA: a faster and more powerful approach for nascent transcriptome analysis
GigaScience·2025Open Access
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies
Proceedings of the National Academy of Sciences·2024· 10 citedOpen Access
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
eLife·2024Open Access
Author response: Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024Open Access
Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
BMC Genomics·2024· 1 citedOpen Access
Author response: Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024Open Access
Reviewer #2 (Public Review): Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024Open Access
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024· 1 citedOpen Access
Reviewer #1 (Public Review): Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024Open Access
Super-Enhancer Dysregulation in Rhabdoid Tumor Cells Is Regulated by the SWI/SNF ATPase BRG1
Cancers·2024· 2 citedOpen Access
Scalable single-cell pooled CRISPR screens with conventional knockout vector libraries
2024· 1 citedOpen Access
WD Repeat Domain 5 Inhibitors for Cancer Therapy: Not What You Think
Journal of Clinical Medicine·2024· 13 citedOpen Access
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors
Journal of Medicinal Chemistry·2023· 9 citedOpen Access
Reviewer #2 (Public Review): Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2023Open Access
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2023· 1 citedOpen Access
Reviewer #1 (Public Review): Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2023Open Access
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
eLife·2023· 18 citedOpen Access
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2023· 1 citedOpen Access
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Frequent Co-authors

Lance R. Thomas(11), Stephen W. Fesik(10), Shelly L. Lorey(9), Simone E Salghetti(8), April M. Weissmiller(8), Audra F. Bryan(6), Gregory C. Howard(6), J. Grace Shaw(6), Jason Phan(5), Edward T. Olejniczak(5), Christine M. Eischen(5), Jonathan D. Macdonald(5), Bin Zhao(5), Shaun R. Stauffer(5), Masafumi Muratani(4), Andreas Herbst(4), Kathryn A Tworkowski(4), Fuqiang Geng(4), Qi Liu(4), Erin R. Aho(4)