Rudolph E. Tanzi

Boston University — United States

Medicine · Health Sciences

143h-index110.0kcitations832works9.92yr avg
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Research Topics

Alzheimer's disease research and treatments(442), Cholinesterase and Neurodegenerative Diseases(87), Bioinformatics and Genomic Networks(77), Neuroinflammation and Neurodegeneration Mechanisms(64), Computational Drug Discovery Methods(61)

Publications811 total

Machine Learning-Enhanced Hyperspectral Raman Imaging for Label-Free Molecular Atlas of Alzheimer’s Brain
ACS Applied Materials & Interfaces·2025
Discovery of Abundant Nano-scale Lymphatic-like Vessels in Brains
2025Open Access
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons
Nature Neuroscience·2025· 3 cited
Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial
EClinicalMedicine·2025Open Access
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function
Neuron·2025· 4 citedOpen Access
Increase of brain Aβ peptides and secretase activity during normal aging in rodent and human
GeroScience·2025Open Access
Efficacy of AD04, an aluminum-based vaccine adjuvant, in patients with early Alzheimer's disease: Post hoc analysis of AFF006 (NCT01117818), a proof-of-concept, phase 2 randomized controlled trial
Journal of Alzheimer s Disease·2025· 1 cited
Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease
Science Translational Medicine·2025· 1 citedOpen Access
Human amylin is a potent antimicrobial peptide that exhibits antimicrobial synergism with the amyloid beta protein
Alzheimer s & Dementia·2025· 2 citedOpen Access
Context-dependent regulatory variants in Alzheimer’s disease
2025· 1 citedOpen Access
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids
Science Advances·2025· 5 citedOpen Access
Evasion of complement and amyloid-beta by the neurotropic pathogen Borrelia burgdorferi in human 3D cultures
Immunobiology·2025· 1 citedOpen Access
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease
Science Signaling·2025· 1 citedOpen Access
Inhibition of Acyl-CoA: Cholesterol Acyltransferase 1 Promotes Shedding of Soluble TREM2 and LRP1-Dependent Phagocytosis of Amyloid β Protein in Microglia
2025Open Access
Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study
GeroScience·2025· 1 cited
Uncovering Ethnicity‐Specific Recessive Loci for Alzheimer's Disease in 89 Dominican Families Using Family‐Based WGS Analysis
Genetic Epidemiology·2025
The Brain Care Score and its associations with cardiovascular disease and cancer
Family Practice·2025· 1 citedOpen Access
Acute experimental colitis in 5xFAD Alzheimer's disease mice leads to enhanced monocyte infiltration into the brain accompanied by reduced β‐amyloid deposition
Alzheimer s & Dementia·2025· 2 citedOpen Access
Use of the Brain Care Score to Estimate the Risk of Incident Cerebrovascular Events in Middle-Aged Women
Neurology·2025· 2 cited
Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer’s disease using a recessive mode of inheritance
2025· 1 citedOpen Access
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Frequent Co-authors

Ashley I. Bush(13), Robert D. Moir(11), Lars Bertram(10), James F. Gusella(7), Colin L. Masters(7), Xudong Huang(7), Lee E. Goldstein(6), Kristina Mullin(5), Deborah Blacker(5), Craig Atwood(5), Bradley T. Hyman(5), Wilma Wasco(4), Robert A. Cherny(4), Se Hoon Choi(4), Richard C. Scarpa(4), Thomas D. Bird(3), Peter St George‐Hyslop(3), Donna Romano(3), Dennis J. Selkoe(3), Paul C. Watkins(3)