Alessandro Carugo

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index4.5kcitations155works3.02yr avg
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Research Topics

Cancer Genomics and Diagnostics(46), Pancreatic and Hepatic Oncology Research(36), Cancer, Hypoxia, and Metabolism(25), Chromatin Remodeling and Cancer(23), Epigenetics and DNA Methylation(19)

Publications155 total

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
Cancer Cell·2026
Abstract 4773: AM E3-SG3249, a first-in-class α-CRLF2 antibody-drug conjugate for the treatment of CRLF2-rearranged Ph-like B-ALL
Cancer Research·2025
Abstract 5614: Advancing treatment for brain tumors and metastases with brain permeable SHP2 inhibitor I-1000233
Cancer Research·2025
Evolutionary fingerprints of epithelial-to-mesenchymal transition
Nature·2025· 21 cited
The mutational landscape and functional effects of noncoding ultraconserved elements in human cancers
Science Advances·2025· 6 citedOpen Access
WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer
2024· 2 citedOpen Access
Abstract 4304: Chromosome 3 dosage-loss informs on the unique biology underlying ultra high-risk uveal melanoma
Cancer Research·2024
Abstract 1975: Discovery of I-1000233, a potent, selective and brain permeable SHP2 allosteric inhibitor
Cancer Research·2024
Abstract 2610: Discovery of AM E3: A novel α-TLSPR monoclonal antibody for the ADC treatment of CRLF2-rearranged Ph-like B-ALL
Cancer Research·2024
Abstract 1758: Chromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanoma
Cancer Research·2024
Abstract 1494: Clonal dominance defines metastatic dissemination in pancreatic cancer
Cancer Research·2024
Clonal dominance defines metastatic dissemination in pancreatic cancer
Science Advances·2024· 7 citedOpen Access
1498 Deploying spatial transcriptomics to inform on intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samples
Regular and Young Investigator Award Abstracts·2023· 1 citedOpen Access
Evolutionary fingerprints of EMT in pancreatic cancers
2023· 4 citedOpen Access
Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer
Nature Cancer·2023· 22 citedOpen Access
SMARCB1 regulates the hypoxic stress response in sickle cell trait
Proceedings of the National Academy of Sciences·2023· 23 citedOpen Access
Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy
Clinical and Translational Medicine·2023· 19 citedOpen Access
Abstract 92: Deploying spatial transcriptomics to inform intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samples
Cancer Research·2023
Abstract 94: Advanced preclinical modeling reveals unique monosomy 3 associated biology in late-stage uveal melanoma
Cancer Research·2023
Data from Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma
2023Open Access
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Frequent Co-authors

Timothy P. Heffernan(33), Giulio Draetta(29), Giannicola Genovese(24), Christopher A. Bristow(22), Andrea Viale(20), Michael Peoples(19), Virginia Giuliani(15), Angela K. Deem(14), Sahil Seth(13), Melinda Soeung(12), Rosalba Minelli(12), Ningping Feng(11), Luigi Perelli(11), Jason B. Fleming(10), Federica Carbone(10), Pavlos Msaouel(10), Haoqiang Ying(9), Anirban Maitra(9), Frederick S. Robinson(9), Nizar M. Tannir(9)