Steven M. Peseckis

University of Toledo — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index799citations28works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(10), Neuropeptides and Animal Physiology(6), Asymmetric Synthesis and Catalysis(4), Microbial Natural Products and Biosynthesis(4), Chemical Synthesis and Analysis(4)

Publications28 total

Fatty acylation enhances cellular localization of dansylated phenylalanines
Molecular and Cellular Biochemistry·2010
Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors
Pharmaceutica Acta Helvetiae·2000· 19 cited
ChemInform Abstract: First Fatty Acylated Dipeptides to Affect Muscarinic Receptor Ligand Binding.
ChemInform·2000
First fatty acylated dipeptides to affect muscarinic receptor ligand binding
Bioorganic & Medicinal Chemistry Letters·1999· 8 citedOpen Access
Differential Modulation of Agonist Potency and Receptor Coupling by Mutations of Ser388Tyr and Thr389Pro at the Junction of Transmembrane Domain VI and the Third Extracellular Loop of Human M1 Muscarinic Acetylcholine Receptors
Molecular Pharmacology·1999· 12 cited
Roles of threonine 192 and asparagine 382 in agonist and antagonist interactions with M<sub>1</sub> muscarinic receptors
British Journal of Pharmacology·1999· 46 citedOpen Access
Mutant M1 muscarinic receptors with increased agonist affinity and G protein coupling
Life Sciences·1999
Mutant M1 muscarinic receptors with enhanced agonist activity
Life Sciences·1999· 1 cited
Pharmacological Characterization of Human m1 Muscarinic Acetylcholine Receptors with Double Mutations at the Junction of TM VI and the Third Extracellular Domain
Journal of Pharmacology and Experimental Therapeutics·1998· 13 cited
ASN382 is critical in ligand binding and activation of human m1 muscarinic receptors
The Society for Neuroscience Abstracts·1998
Molecular studies of agonist interactions with wild-type, T234A, and N507A m3 receptors
Life Sciences·1997
[34] Synthesis and use of iodo-fatty acid analogs
Methods in enzymology on CD-ROM/Methods in enzymology·1995· 46 cited
Fatty acyl transfer by human N-myristyl transferase is dependent upon conserved cysteine and histidine residues.
Journal of Biological Chemistry·1994· 48 citedOpen Access
Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization
Journal of Biological Chemistry·1994· 208 citedOpen Access
Regulation of enzymatic activity by active site fatty acylation. A new role for long chain fatty acid acylation of proteins.
Journal of Biological Chemistry·1994· 71 citedOpen Access
Novel use of an iodo-myristyl-CoA analog identifies a semialdehyde dehydrogenase in bovine liver
Journal of Biological Chemistry·1993· 20 citedOpen Access
Iodinated fatty acids as probes for myristate processing and function. Incorporation into pp60v-src.
Journal of Biological Chemistry·1993· 59 citedOpen Access
ChemInform Abstract: Chemistry and Positive Inotropic Effect of Pelrinone and Related Derivatives. A Novel Class of 2‐Methylpyrimidones as Inotropic Agents.
ChemInform·1988
Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents
Journal of Medicinal Chemistry·1988· 22 citedOpen Access
ChemInform Abstract: SYNTHESIS OF ANTIBIOTIC X‐14547A
Chemischer Informationsdienst·1985
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Frequent Co-authors

William S. Messer(10), Frederick E. Williams(7), Marilyn D. Resh(6), William Roush(5), Luc G. Berthiaume(4), Péter Nagy(4), X.-P. Huang(4), Ida Deichaite(3), Xi‐Ping Huang(3), Michael A. Adam(2), Alan E. Walts(2), Jehan F. Bagli(2), T. BOGRI(2), B. Palameta(2), S. Rakhit(2), Jeff McQuillan(2), D. K. H. Lee(2), Vyjayanthi Krishnan(2), Wellington Pham(2), W. R. ROUSH(2)