Toby Passioura

The University of Sydney — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index1.9kcitations81works2.82yr avg
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Research Topics

Chemical Synthesis and Analysis(22), RNA and protein synthesis mechanisms(15), Protein Degradation and Inhibitors(11), Peptidase Inhibition and Analysis(10), RNA Interference and Gene Delivery(8)

Publications81 total

<i>De novo</i> cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3
Biochemical Journal·2026Open Access
The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides
Chemical Communications·2026
Cell-Active Peptide Inhibitors of the FANCM-RMI Interaction
Journal of Medicinal Chemistry·2025
<i>De novo</i> Cyclic Peptides Allow Visualisation of the Monomeric and Functional Amyloid Conformations of the Kinase RIPK3
2025Open Access
Cell-active peptide inhibitors of the FANCM-RMI interaction
2025
Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics
2025Open Access
Cell-active peptide inhibitors of the FANCM-RMI interaction
2025
Potent Cyclic Peptide Inhibitors Disrupt the FANCM–RMI Interaction
Journal of Medicinal Chemistry·2025· 4 cited
An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase
Nature Communications·2025· 7 citedOpen Access
Development of selective nanomolar cyclic peptide ligands as GBA1 enzyme stabilisers
RSC Chemical Biology·2025· 3 citedOpen Access
Macrocyclic peptides as a new class of targeted protein degraders
RSC Chemical Biology·2025· 4 citedOpen Access
Translational synthesis of constrained cyclic peptides using genetic code reprogramming
Methods in enzymology on CD-ROM/Methods in enzymology·2025
Development of Selective Nanomolar Cyclic Peptide Ligands as GBA1 Enzyme Stabilisers
2024
A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model
iScience·2024· 1 citedOpen Access
The coming of age of cyclic peptide drugs: an update on discovery technologies
Expert Opinion on Drug Discovery·2024· 23 cited
Discovery of High Affinity Cyclic Peptide Ligands for Human ACE2 with SARS-CoV-2 Entry Inhibitory Activity
ACS Chemical Biology·2023· 11 cited
mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome
Journal of Biological Chemistry·2023· 5 citedOpen Access
Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins
Structure·2023· 12 citedOpen Access
mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome
2023· 2 citedOpen Access
Data from &lt;i&gt;N-Ras&lt;/i&gt;–Induced Growth Suppression of Myeloid Cells Is Mediated by &lt;i&gt;IRF-1&lt;/i&gt;
2023Open Access
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Frequent Co-authors

Hiroaki Suga(30), Richard J. Payne(10), Geoff Symonds(8), Karishma Patel(7), Joel P. Mackay(7), Alla Dolnikov(7), Sylvie Shen(6), Louise J. Walport(5), Jason K. K. Low(5), Takayuki Katoh(4), Alexander Norman(4), Charlotte Franck(4), Amber Goodchild(4), Andrew King(4), Laurent P. Rivory(4), Jason Johansen‐Leete(4), Daniel Ford(4), Yuki Goto(3), Mary Christie(3), Anneliese S. Ashhurst(3)