Edouard De Dreuzy

Editas Medicine (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

6h-index278citations14works0.32yr avg
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Research Topics

Virus-based gene therapy research(5), Hemoglobinopathies and Related Disorders(4), Immunotherapy and Immune Responses(4), CRISPR and Genetic Engineering(4), Prenatal Screening and Diagnostics(4)

Publications14 total

Nonclinical evaluation of renizgamglogene autogedtemcel for SCD and TDT
Molecular Therapy·2025Open Access
Abstract 4260: ADV-101: a novel ADC targeting IL-1RAP, leveraging tumor cell and the tumor microenvironment vulnerabilities for enhanced anti-tumor efficacy
Cancer Research·2025
Resolve AML 001: An Adaptive Open-Label Multicentre Phase 1/2 Trial, to Determine the Recommended Phase 2 Dose of Cctx-001, and to Assess Safety, Tolerability, and Clinical Activity in Patients with r/r AML
Blood·2024· 1 citedOpen Access
IL-1RAP Is a Targetable Surface Antigen in Relapsed/Refractoy AML
Blood·2024Open Access
Abstract 6322: CCTx-001 CAR T-cells targeting the AML specific antigen IL-1RAP show robust pre-clinical anti-tumor efficacy
Cancer Research·2024
Abstract 2360: ADV101, a first-in-class IL-1RAP ADC demonstrates significant anti-tumor activity in solid tumor models
Cancer Research·2024· 1 cited
Robust Pre-Clinical Results and Large-Scale Manufacturing Process for Edit-301: An Autologous Cell Therapy for the Potential Treatment of SCD
Blood·2020· 1 cited
EDIT-301: An Experimental Autologous Cell Therapy Comprising Cas12a-RNP Modified mPB-CD34+ Cells for the Potential Treatment of SCD
Blood·2019· 30 cited
PS1518 GENOME EDITING OF HBG1/2 PROMOTER LEADS TO ROBUST HBF INDUCTION IN VIVO, WHILE EDITING OF BCL11A ERYTHROID ENHANCER RESULTS IN ERYTHROID DEFECTS
HemaSphere·2019· 8 citedOpen Access
Ex Vivo Selection of Transduced Hematopoietic Stem Cells for Gene Therapy of β-Hemoglobinopathies
Molecular Therapy·2017· 17 citedOpen Access
Current and future alternative therapies for beta-thalassemia major
Biomedical Journal·2016· 90 citedOpen Access
Ciblage chromosomique des vecteurs lentiviraux, risque génotoxique, dominance clonale et expansion des cellules souches hématopoïétiques
2016
Transplantation of Macaca cynomolgus iPS-derived hematopoietic cells in NSG immunodeficient mice
Haematologica·2015· 13 citedOpen Access
Preclinical Evaluation of Efficacy and Safety of an Improved Lentiviral Vector for the Treatment of β-Thalassemia and Sickle Cell Disease
Current Gene Therapy·2014· 117 citedOpen Access

Frequent Co-authors

Marina Deschamps(5), Christophe Ferrand(5), Richard C.A. Sainson(5), Jens Hasskarl(5), Emmanuel Payen(4), Patricia Sousa(4), Philippe Leboulch(3), Anaïs Paulard(3), Jack Heath(3), John A. Zuris(3), Ramya Viswanathan(3), Kai‐Hsin Chang(3), Delphine Genin(3), Lucie Bouquet(3), Erik Rutjens(3), Olivier Nègre(2), Maria Denaro(2), Béatrix Gillet-Legrand(2), Leïla Maouche(2), Kanit Bhukhai(2)