Yasuha Arai

Kyoto Prefectural University of Medicine — Japan

Medicine · Health Sciences

13h-index532citations30works1.02yr avg
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Research Topics

Influenza Virus Research Studies(23), Respiratory viral infections research(13), Viral gastroenteritis research and epidemiology(8), Animal Disease Management and Epidemiology(6), SARS-CoV-2 and COVID-19 Research(5)

Publications30 total

Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection
PLoS Pathogens·2026Open Access
The host tropism of current zoonotic H7N9 viruses depends mainly on an acid-labile hemagglutinin with a single amino acid mutation in the stalk region
PLoS Pathogens·2024· 2 citedOpen Access
Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists
iScience·2022· 10 citedOpen Access
ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific manner
Communications Biology·2022· 38 citedOpen Access
Stimulation of dysregulated IFN-β responses by aberrant SARS-CoV-2 small viral RNAs
Research Square (Research Square)·2022· 1 citedOpen Access
Stimulation of dysregulated IFN-β responses by aberrant SARS-CoV-2 small viral RNAs acting as RIG-I agonists
Research Square (Research Square)·2022· 1 citedOpen Access
Development of genus-specific universal primers for the detection of flaviviruses
Virology Journal·2021· 8 citedOpen Access
Double mutations in the H9N2 avian influenza virus PB2 gene act cooperatively to increase viral host adaptation and replication for human infections
Journal of General Virology·2021· 7 cited
“Genetic tuning” of avian influenza virus host adaptation from birds to humans
Biosafety and Health·2020· 3 citedOpen Access
PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range
Journal of Virology·2020· 24 citedOpen Access
H9N2 Influenza Virus Infections in Human Cells Require a Balance between Neuraminidase Sialidase Activity and Hemagglutinin Receptor Affinity
Journal of Virology·2020· 27 citedOpen Access
Infection of Human Tracheal Epithelial Cells by H5 Avian Influenza Virus Is Regulated by the Acid Stability of Hemagglutinin and the pH of Target Cell Endosomes
Viruses·2020· 10 citedOpen Access
Accumulation of PA mutations in Egyptian H5N1 viruses during viral evolution conferred the increased replication ability.
The Japanese Society for Virology·2019
PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals
PLoS Pathogens·2019· 49 citedOpen Access
Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals
Journal of Virology·2018· 38 citedOpen Access
Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates
Scientific Reports·2018· 29 citedOpen Access
Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells
Journal of Virology·2018· 20 citedOpen Access
Immunohistochemical Expression of Synaptophysin in the Adult and Developing Cervical and Lumbar Enlargements of the Spinal Cord of Rabbit
Academia Anatomica International·2018· 1 citedOpen Access
Anatomical spatial distribution of Influenza virus receptors in some poultry species raised in Egypt
Academia Anatomica International·2018Open Access
Unique Infectious Strategy of H5N1 Avian Influenza Virus Is Governed by the Acid-Destabilized Property of Hemagglutinin
Viral Immunology·2017· 10 cited
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Frequent Co-authors

Y. Watanabe(26), Takaaki Nakaya(24), Tomo Daidoji(23), Madiha S. Ibrahim(16), Kazuhiko Matsumoto(11), Emad Mohamed Elgendy(10), Takao Ono(10), Norihito Kawashita(9), Tatsuya Takagi(8), Yasuo Suzuki(8), Kazuyoshi Ikuta(6), Ayana Isobe(5), Ritsuko Kubota‐Koketsu(4), Nongluk Sriwilaijaroen(4), Ryohei Hirose(3), Kazuo Takahashi(3), Tatsuo Shioda(3), Hiroaki Hiramatsu(3), Yoshinobu Okuno(3), Junichi Kajikawa(3)