Christopher M. Overall

University of British Columbia — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

99h-index38.9kcitations413works5.42yr avg
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Research Topics

Protease and Inhibitor Mechanisms(142), Peptidase Inhibition and Analysis(109), Advanced Proteomics Techniques and Applications(72), Cell Adhesion Molecules Research(47), Blood Coagulation and Thrombosis Mechanisms(47)

Publications411 total

Finerenone prevents renal damage by enhancing SDF-1α/CXCR4-mediated stem cell mobilization in experimental type 1 diabetic nephropathy
Biomedicine & Pharmacotherapy·2025Open Access
Hydrolases & Lipases in GtoPdb v.2025.3
IUPHAR/BPS Guide to Pharmacology CITE·2025Open Access
Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells
Cell Reports·2025· 2 citedOpen Access
Hydrolases & Lipases in GtoPdb v.2025.2
IUPHAR/BPS Guide to Pharmacology CITE·2025Open Access
YibN, a bona fide interactor of the bacterial YidC insertase with effects on membrane protein insertion and membrane lipid production
Journal of Biological Chemistry·2025· 1 citedOpen Access
Strategic priorities for transformative progress in advancing biology with proteomics and artificial intelligence
arXiv (Cornell University)·2025Open Access
Flagellinolysin: bacterial flagellar metallopeptidase
Handbook of Proteolytic Enzymes·2025
Author Correction: π-HuB: the proteomic navigator of the human body
Nature·2024· 2 citedOpen Access
YibN, a bona fide interactor of YidC with implications in membrane protein insertion and membrane lipid production
2024· 2 citedOpen Access
π-HuB: the proteomic navigator of the human body
Nature·2024· 34 citedOpen Access
Hydrolases & Lipases in GtoPdb v.2024.4
IUPHAR/BPS Guide to Pharmacology CITE·2024· 1 citedOpen Access
SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro
Cell Reports·2024· 7 citedOpen Access
The 2024 Report on the Human Proteome from the HUPO Human Proteome Project
Journal of Proteome Research·2024· 19 citedOpen Access
Identification of the proteolytic signature in CVB3-infected cells
Journal of Virology·2024· 2 citedOpen Access
Hydrolases & Lipases in GtoPdb v.2024.2
IUPHAR/BPS Guide to Pharmacology CITE·2024Open Access
Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CL <sup>pro</sup> main protease (Mpro) from proteomic identification of P6—P6' active site specificity
Journal of Virology·2024· 7 citedOpen Access
SARS-CoV-2 3CLpro Main Protease Drives Cytoskeletal Reorganization and Tunnelling Nanotube Formation for Stealth Intercellular Infection
Research Square (Research Square)·2024Open Access
The 2023 Report on the Proteome from the HUPO Human Proteome Project
Journal of Proteome Research·2024· 26 citedOpen Access
Hydrolases &amp; Lipases in GtoPdb v.2023.3
IUPHAR/BPS Guide to Pharmacology CITE·2023Open Access
Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9
Matrix Biology·2023· 23 citedOpen Access
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Frequent Co-authors

Georgina S. Butler(9), Carlos López-Otı́n(5), Jonathan Kipnis(5), Ulrich auf dem Keller(5), Richard A. Dean(5), Igor Smirnov(4), Ian Clark‐Lewis(4), Charlotte Morrison(4), Anna Prudova(4), Amanda E. Starr(4), Antoine Dufour(4), Antoine Louveau(3), Oded Kleifeld(3), Eric M. Tam(3), G. Angus McQuibban(3), Jaro Sodek(3), David Rodrı́guez(3), Alain Doucet(3), Oliver Schilling(3), Caroline L. Bellac(3)