Anne Chew

California University of Pennsylvania — United States

Medicine · Health Sciences

28h-index17.0kcitations89works11.12yr avg
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Research Topics

CAR-T cell therapy research(63), Immune Cell Function and Interaction(13), Virus-based gene therapy research(12), Immunotherapy and Immune Responses(10), Chronic Lymphocytic Leukemia Research(10)

Publications89 total

Cell-derived Nanoparticles Provide a Robust Platform to Manufacture Therapeutic T cells.
2026Open Access
Phase 1 study of autologous T cells bearing fully human chimeric antigen receptors targeting mesothelin in mesothelin-expressing cancers
Molecular Therapy·2026
Humanized CD19 chimeric antigen receptor (CAR) T-cell therapy for high-risk and post-CAR relapse of B-cell acute lymphoblastic leukemia
Blood·2025
Lipid nanoparticle-mediated epitope editing in human HSPCs enables resistance to CD45-directed CAR-T cell therapy
Blood·2025Open Access
557 Evaluation of huCART19-IL18 manufactured using Synecta™ CDNP technology to improve CAR-T yield and consistency in cohort D of an ongoing phase I study (NCT04684563)
Regular and Young Investigator Award Abstracts·2025Open Access
CCR5-targeted allogeneic gamma–delta CD19 chimeric antigen receptor T cells for HIV-associated B cell-malignancy immunotherapy
Nature Biomedical Engineering·2025· 1 cited
Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure
New England Journal of Medicine·2025· 59 cited
Masquerade syndrome secondary to choroidal melanoma in a 73-year-old patient
Latin American Journal of Ophthalmology·2025Open Access
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies
Nature Medicine·2025· 58 cited
Editor’s Note: Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor
Cancer Research·2024· 1 citedOpen Access
Phase I clinical trial of autologous T cells bearing fully humanized chimeric antigen receptors targeting mesothelin with both intravenous administration and local delivery with or without lymphodepletion in mesothelin-expressing cancers, including ovarian cancer
Gynecologic Oncology·2024
Long-term stability of clinical-grade lentiviral vectors for cell therapy
Molecular Therapy — Methods & Clinical Development·2024· 14 citedOpen Access
671 Phase 1 trial of human chimeric antigen receptor modified T cells (huCART-meso) administered in combination with oncolytic virus VCN-01 in patients with pancreatic and ovarian cancer
Regular and Young Investigator Award Abstracts·2023· 1 citedOpen Access
Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells
Molecular Therapy·2023· 78 citedOpen Access
Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors
Cell Reports Medicine·2023· 57 citedOpen Access
Regulatory Affairs, Quality Systems, Policy, and Ethics: FDA CYTOTOXICITY AND POTENCY REVIEW: OPPORTUNITIES FOR ASSAY CLARITY
Cytotherapy·2023
Data from Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
2023Open Access
Data from Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
2023Open Access
Supplemental Materials, Figures 1 - 4, Tables 1 - 4 from Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
2023Open Access
Supplemental Materials, Figures 1 - 4, Tables 1 - 4 from Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
2023Open Access
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Frequent Co-authors

Carl H. June(43), Bruce L. Levine(37), Simon F. Lacey(24), David L. Porter(19), J. Joseph Melenhorst(18), Stephan A. Grupp(15), Katherine T. Marcucci(13), Joseph A. Fraietta(13), Wei‐Ting Hwang(12), Noelle V. Frey(11), Vanessa Gonzalez(11), Zhaohui Zheng(11), Michael Kalos(11), Alison W. Loren(10), Gabriela Plesa(10), Holly McConville(10), Stephen J. Schuster(10), Pamela A. Shaw(9), Megan M. Davis(9), Jakub Svoboda(9)