Albert J. R. Heck

Utrecht University — Netherlands

Chemistry · Physical Sciences

132h-index70.9kcitations1.1kworks5.02yr avg
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Research Topics

Mass Spectrometry Techniques and Applications(294), Advanced Proteomics Techniques and Applications(263), Monoclonal and Polyclonal Antibodies Research(107), Glycosylation and Glycoproteins Research(97), Enzyme Structure and Function(81)

Publications1.1k total

AI‐driven antibody design from an antigen sequence
Vita·2026Open Access
Uncovering the link between ATP synthase and the TCA cycle by crosslinking mass spectrometry
2025Open Access
Widespread Fab-arm exchange affects all endogenous serum IgG4
Nature Communications·2025· 1 citedOpen Access
The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches
Frontiers in Nutrition·2025Open Access
Structural promiscuity in the human circulatory IgA1 clonal repertoire
2025Open Access
Immunoglobulin sub-class levels define inter-donor plasma variability: a longitudinal dual-lab study
2025Open Access
A prototype timsOmni platform enables confident annotation of key hypervariable regions of IgG immunoglobulins using low- and high-energy electron-based fragmentation
2025Open Access
A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics
Analytical Chemistry·2025· 2 citedOpen Access
Fucosylation limits <scp>ADCC</scp> in clinically used anti‐<scp>RhD</scp> monoclonal antibodies
Transfusion·2025Open Access
Epigenetic risk stratification in juvenile myelomonocytic leukemia by targeted methylation analysis of the BMP4 locus
Clinical Epigenetics·2025Open Access
Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens
Cell Reports Medicine·2025Open Access
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport
Immunity & Ageing·2025· 1 citedOpen Access
Increased EThcD Efficiency on the Hybrid Orbitrap Excedion Pro Mass Analyzer Extends the Depth in Identification and Sequence Coverage of HLA Class I Immunopeptidomes
Molecular & Cellular Proteomics·2025· 5 citedOpen Access
Characterisation of the manchette architecture and its role as transport scaffold using cryo-electron tomography
Life Science Alliance·2025· 2 citedOpen Access
Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP
Molecular & Cellular Proteomics·2025· 2 citedOpen Access
Mannan interference and purification efficiency in downstream processing of precision-fermented milk proteins from Komagataella phaffii
Future Foods·2025· 2 citedOpen Access
Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry
Molecular Therapy — Nucleic Acids·2025Open Access
Author Correction: The kinase TNIK is an essential activator of Wnt target genes
The EMBO Journal·2025Open Access
A Roadmap for Improving Reliability and Data Sharing in Crosslinking Mass Spectrometry
Molecular & Cellular Proteomics·2025· 2 citedOpen Access
Analytical Challenges in Analyzing <scp>IgM</scp> Biotherapeutics
2025· 1 cited
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Frequent Co-authors

Shabaz Mohammed(15), Teck Yew Low(5), Ruedi Aebersold(5), Jeroen Krijgsveld(5), Paul J. Boersema(4), Hans Clevers(4), Maarten Altelaar(4), Bon‐Kyoung Koo(3), Marc van de Wetering(3), Daniel E. Stange(3), Johan H. van Es(3), Javier Muñoz(3), Esther van Duijn(3), Arjan Barendregt(3), Jennifer A. Doudna(3), Nick Barker(2), Vivian Li(2), Madelon M. Maurice(2), Martijn W. H. Pinkse(2), Tokameh Mahmoudi(2)