Dario R. Alessi

MRC Protein Phosphorylation and Ubiquitylation Unit — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

141h-index83.9kcitations537works6.12yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(123), Cellular transport and secretion(105), PI3K/AKT/mTOR signaling in cancer(104), Parkinson's Disease Mechanisms and Treatments(89), Metabolism, Diabetes, and Cancer(70)

Publications534 total

Abstract A007: Early Signaling Networks of Anti-CD19 CAR-T Cells Revealed by Quantitative Proteomic and Phosphoproteomic Profiling
Cancer Immunology Research·2026
FALCON-qPCR: a new method for the quantification of oxidative lesions in mitochondrial DNA
Bioanalysis·2025Open Access
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif
Structure·2025Open Access
Molecular profiling of brain endothelial cell to astrocyte endfoot communication in mouse and human
Nature Communications·2025· 3 citedOpen Access
Reinventing Chemiluminescence through Redox-Driven Self-Assembly
Journal of the American Chemical Society·2025Open Access
Alternative Splicing Directs PMCA2 to Lysosomes and is Linked to Neurodegeneration
2025Open Access
WNK Condensate Formation Drives Kinase Activation and Regulates Electrolyte Homeostasis
Journal of the American Society of Nephrology·2025
Mimicking Life and Death in a Photocatalytic Supramolecular System
2025
Precision Stratification: Kinase Assay in Asian <i>LRRK2</i> Risk Carriers and Idiopathic Parkinson Disease
2025· 1 citedOpen Access
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
2025Open Access
Dynamic Reconfiguration of Pt(II) Supramolecular Assemblies via Ligand Exchange
ACS Applied Materials & Interfaces·2025· 1 citedOpen Access
TDP-43 loss of function drives aberrant splicing in Parkinson’s disease
2025Open Access
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
2025Open Access
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif
2025Open Access
Generation of HEK293 TMEM55B and TMEM55A CRISPR/Cas9 double knock-out cell line v1
2025Open Access
Functional and Structural Characterization of <scp>LRRK2</scp> p. <scp>V1447L</scp> in Parkinson's Disease
Movement Disorders·2025· 1 citedOpen Access
Proteomics analysis reveal early event molecular effectors of anti-CD19 CAR-T cell therapy in hematological cancer
Journal of Proteomics·2025· 1 citedOpen Access
PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson’s disease
Cell Reports·2025· 1 citedOpen Access
NRBP1 and TSC22D proteins affect distal convoluted tubule physiology through modulation of the WNK pathway
Science Advances·2025· 2 citedOpen Access
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress
Science Advances·2025· 1 citedOpen Access
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Frequent Co-authors

Philip Cohen(12), Mária Deák(10), Kei Sakamoto(5), Brian A. Hemmings(4), Jérôme Boudeau(4), Nick Morrice(4), Mirjana Andjelković(3), C. Peter Downes(3), Piers R. J. Gaffney(3), Natalia Shpiro(3), D. Grahame Hardie(3), David G. Campbell(3), Robert Gourlay(3), Axel Knebel(3), R. Jeremy Nichols(3), Nicolas Dzamko(3), Alan R. Prescott(3), Darren A.E. Cross(2), Peter Cron(2), Colin B. Reese(2)