Diego García Jiménez

University of Turin — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index582citations12works20.32yr avg

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Research Topics

Protein Degradation and Inhibitors(11), Ubiquitin and proteasome pathways(10), Peptidase Inhibition and Analysis(6), Multiple Myeloma Research and Treatments(3), Computational Drug Discovery Methods(2)

Publications12 total

Linker Methylation as a Strategy to Enhance PROTAC Oral Bioavailability: Insights from Molecular Properties and Conformational Analysis

5 cited

Journal of Medicinal Chemistry·2025· 5 citedOpen Access

Molecular properties, including chameleonicity, as essential tools for designing the next generation of oral beyond rule of five drugs

9 cited

ADMET & DMPK·2024· 9 citedOpen Access

IMHB-Mediated Chameleonicity in Drug Design: A Focus on Structurally Related PROTACs

22 cited

Journal of Medicinal Chemistry·2024· 22 cited

Exploring the chemical space of orally bioavailable PROTACs

45 cited

Drug Discovery Today·2024· 45 citedOpen Access

Chamelogk: A Chromatographic Chameleonicity Quantifier to Design Orally Bioavailable Beyond-Rule-of-5 Drugs

36 cited

Journal of Medicinal Chemistry·2023· 36 citedOpen Access

Macrocycles in Drug Discovery─Learning from the Past for the Future

235 cited

Journal of Medicinal Chemistry·2023· 235 citedOpen Access

Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader

21 cited

Pharmaceutics·2023· 21 citedOpen Access

Refinement of Computational Access to Molecular Physicochemical Properties: From Ro5 to bRo5

27 cited

Journal of Medicinal Chemistry·2022· 27 citedOpen Access

Designing Soluble PROTACs: Strategies and Preliminary Guidelines

81 cited

Journal of Medicinal Chemistry·2022· 81 citedOpen Access

Are we ready to design oral PROTACs®?

21 cited

ADMET & DMPK·2021· 21 citedOpen Access

Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs

35 cited

ACS Medicinal Chemistry Letters·2021· 35 citedOpen Access

PROTACs and Building Blocks: The 2D Chemical Space in Very Early Drug Discovery

45 cited

Molecules·2021· 45 citedOpen Access

Frequent Co-authors

Giuseppe Ermondi(11), Giulia Caron(11), Matteo Rossi Sebastiano(7), Maura Vallaro(6), Jan Kihlberg(3), Giulia Apprato(3), Vasanthanathan Poongavanam(2), Valentina Mileo(1), Daniela Pizzirani(1), Elisa Moretti(1), Yoseph Atilaw(1), Máté Erdélyi(1), Giulia D’Agostini(1), Paolo Rossetti(1), Luigi Vitagliano(1), Lucia Lopez Lopez(1), Zuzana Jandová(1), Heribert Arnhof(1)