John G. DeLuca

MatTek Corporation (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.3kcitations48works0.02yr avg
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Research Topics

Carcinogens and Genotoxicity Assessment(15), DNA Repair Mechanisms(13), Peroxisome Proliferator-Activated Receptors(9), Drug Transport and Resistance Mechanisms(5), Metabolism, Diabetes, and Cancer(4)

Publications45 total

Genotoxicity testing using the micronucleus and comet assays in normal human cell based 3D epithelial models
Toxicology Letters·2011· 1 cited
L -Amphetamine improves memory in MS patients with memory impairment
2011· 2 cited
An Evaluation of Chronic 6- and 12-Month Rat Toxicology Studies as Predictors of 2-Year Tumor Outcome
Veterinary Pathology·2010· 52 cited
PPARα and Effects of TCE
Environmental Health Perspectives·2007· 1 citedOpen Access
PPARα and Effects of TCE
Environmental Health Perspectives·2007Open Access
PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance
Critical Reviews in Toxicology·2003· 612 cited
Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests
Environmental and Molecular Mutagenesis·2002· 40 cited
Differential Gene Regulation in Human Versus Rodent Hepatocytes by Peroxisome Proliferator-activated Receptor (PPAR) α
Journal of Biological Chemistry·2001· 191 citedOpen Access
Dexamethasone Selectively Inhibits WY14,643-Induced Cell Proliferation and Not Peroxisome Proliferation in Mice
Toxicology and Applied Pharmacology·2001· 13 cited
Evidence for Peroxisome Proliferator-Activated Receptor (PPAR)α-Independent Peroxisome Proliferation: Effects of PPARγ/δ-Specific Agonists in PPARα-Null Mice
Molecular Pharmacology·2000· 2 cited
Evidence for Peroxisome Proliferator-Activated Receptor (PPAR)α-Independent Peroxisome Proliferation: Effects of PPARγ/δ-Specific Agonists in PPARα-Null Mice
Molecular Pharmacology·2000· 53 cited
Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?
Regulatory Toxicology and Pharmacology·1998· 245 cited
The mouse lymphoma L5178Y Tk+/− cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene
Mutation research. Fundamental and molecular mechanisms of mutagenesis·1997· 94 cited
Detection of DNA damage induced by human carcinogens in acellular assays: Potential application for determining genotoxic mechanisms
Mutation Research/Genetic Toxicology·1996· 33 cited
Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds
Mutation Research/Genetic Toxicology·1996· 137 cited
Extent and Persistence of Streptozotocin-Induced DNA Damage and Cell Proliferation in Rat Kidney as Determined by in Vivo Alkaline Elution and BrdUrd Labeling Assays
Toxicology and Applied Pharmacology·1995· 70 cited
Co-purification of gastric mucoproteins with DNA: An explanation for the reported ‘interaction’ of omeprazole with DNA in rat tissues
Mutation Research/Genetic Toxicology·1994· 5 cited
Validation of a flow cytometric in vitro DNA repair (UDS) assay in rat hepatocytes
Mutation Research/DNA Repair·1994· 33 cited
Rapid DNA degradation in primary rat hepatocytes treated with diverse cytotoxic chemicals: Analysis by pulsed field gel electrophoresis and implications for alkaline elution assays
Environmental and Molecular Mutagenesis·1994· 55 cited
Cytotoxicity as measured by trypan blue as a potentially confounding variable in the in vitro alkaline elution/rat hepatocyte assay
Mutation Research/Environmental Mutagenesis and Related Subjects·1993· 45 cited
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Frequent Co-authors

Richard D. Storer(10), William G. Thilly(9), Warren W. Nichols(8), Andrew R. Kraynak(6), Jeffrey M. Peters(5), Michael C. Elia(5), Penelope A. Fenner-Crisp(4), Troy W. McKelvey(4), D.A. Kaden(4), Bruce W. Penman(4), James H. Clair(4), James E. Klaunig(3), Michael A. Babich(3), Jon C. Cook(3), Raymond M. David(3), Richard H. McKee(3), Ruth Roberts(3), David E. Moller(3), John E. Barnum(3), Lori S. Harmon(3)