David A. Gillespie

Universidad de La Laguna — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

41h-index9.2kcitations123works0.02yr avg
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Research Topics

DNA Repair Mechanisms(45), Cancer-related Molecular Pathways(26), Microtubule and mitosis dynamics(22), Protein Kinase Regulation and GTPase Signaling(13), Cell death mechanisms and regulation(12)

Publications123 total

Stabilization of G-Quadruplexes Modulates the Expression of DNA Damage and Unfolded Protein Response Genes in Canine Lymphoma/Leukemia Cells
International Journal of Molecular Sciences·2025Open Access
An initial characterisation of the Unfolded Protein Response pathway in haematopoietic canine cancer cell lines – a necessary step for the future development of new therapies in dogs with neoplasia
Journal of Veterinary Research·2023· 1 citedOpen Access
Studying the DNA damage response pathway in hematopoietic canine cancer cell lines, a necessary step for finding targets to generate new therapies to treat cancer in dogs
Frontiers in Veterinary Science·2023· 4 citedOpen Access
Data from Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde
2023Open Access
Supplementary Figure 1 from Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde
2023Open Access
Data from Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde
2023Open Access
Supplementary Figure 1 from Cells Deficient in the FANC/BRCA Pathway Are Hypersensitive to Plasma Levels of Formaldehyde
2023Open Access
When more is less: heritable gain‐of‐function chk1 mutations impair human fertility
FEBS Journal·2022· 8 citedOpen Access
DNA damage response proteins in canine cancer as potential research targets in comparative oncology
Veterinary and Comparative Oncology·2021· 14 citedOpen Access
The Nucleocapsid protein triggers the main humoral immune response in COVID-19 patients
Biochemical and Biophysical Research Communications·2021· 84 citedOpen Access
Characterization of polymers by LenS3 multiangle light scattering
Elsevier eBooks·2021· 1 cited
Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation
Scientific Reports·2018· 14 citedOpen Access
Claspin – checkpoint adaptor and <scp>DNA</scp> replication factor
FEBS Journal·2018· 105 cited
Targeting CHK1 for Cancer Therapy: Rationale, Progress and Prospects
Cancer drug discovery and develogment/Cancer drug discovery and development·2018
AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11
Oncogene·2017· 46 citedOpen Access
PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1
Oncogene·2016· 48 cited
Autophagy is critically required for DNA repair by homologous recombination
Molecular & Cellular Oncology·2015· 24 citedOpen Access
DNA damage control: regulation and functions of checkpoint kinase 1
FEBS Journal·2015· 110 citedOpen Access
KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage
Scientific Reports·2015· 13 citedOpen Access
Evolutionary Nature of Human Reverse Transcriptase and of Viral-related DNA Synthesized In Vitro by Human Leukemic Cells
Proceedings of the International Symposium on Comparative Leukemia Research·2015· 1 cited
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Frequent Co-authors

Elizabeth J. Black(13), George Zachos(7), Mark Walker(6), Naihan Xu(4), Silvana Libertini(4), Owen J. Sansom(3), Mary T. Scott(3), Carolyn Wiltshire(3), Veronique A. J. Smits(3), Elisa Barrón‐Cabrera(3), Raimundo Freire(3), Gerhard May(3), Helen M.R. Robinson(3), Robert Brown(3), Lye Mun Tho(2), Yuanzhi Lao(2), Yaou Zhang(2), Lisa J. Walker(2), Craig Robson(2), Ian D. Hickson(2)