Markus A. Rüegg

University of Basel — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

77h-index25.6kcitations269works4.52yr avg
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Research Topics

Muscle Physiology and Disorders(102), Ion channel regulation and function(33), PI3K/AKT/mTOR signaling in cancer(31), Cell Adhesion Molecules Research(26), Cellular transport and secretion(21)

Publications267 total

Mini-agrin prevents calcium leakage and restores the dystrophin complex
2025Open Access
Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy
Nature Communications·2025· 1 citedOpen Access
Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy
2025Open Access
Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk
Nature Communications·2025· 6 citedOpen Access
Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy
2025· 1 citedOpen Access
Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis
Nature Communications·2025· 5 citedOpen Access
AAV capsids target muscle-resident cells with different efficiencies—A comparative study between AAV8, AAVMYO, and AAVMYO2
Molecular Therapy — Methods & Clinical Development·2025· 7 citedOpen Access
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
Nature Communications·2025· 19 citedOpen Access
Calorie restriction and rapamycin distinctly restore non-canonical ORF translation in the muscles of aging mice
npj Regenerative Medicine·2024· 3 citedOpen Access
Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles
Communications Biology·2024· 5 citedOpen Access
CaMKIIβ deregulation contributes to neuromuscular junction destabilization in Myotonic Dystrophy type I
Skeletal Muscle·2024· 10 citedOpen Access
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance
2024· 2 citedOpen Access
Muscle fiber Myc is dispensable for muscle growth and forced expression severely perturbs homeostasis
2024Open Access
European Joint Programme on Rare Diseases workshop: LAMA2-muscular dystrophy: paving the road to therapy March 17–19, 2023, Barcelona, Spain
Neuromuscular Disorders·2024· 4 citedOpen Access
P428 Biochemical changes in chorionic villi of LAMA2-patients resemble muscle relevant disease processes
Neuromuscular Disorders·2023
P423 AAV-mediated therapeutic effect of linker protein-mediated gene therapy on muscle and nerve pathology in mouse models for LAMA2 MD
Neuromuscular Disorders·2023
Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9
Nature Communications·2023· 23 citedOpen Access
Raptor levels are critical for β-cell adaptation to a high-fat diet in male mice
Molecular Metabolism·2023· 5 citedOpen Access
Nerve pathology is prevented by linker proteins in mouse models for <i>LAMA2</i> -related muscular dystrophy
PNAS Nexus·2023· 12 citedOpen Access
Destabilization of neuromuscular junctions and deregulation of activity-dependent signalling pathways in Myotonic Dystrophy type I
2023Open Access
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Frequent Co-authors

Michael N. Hall(16), Shuo Lin(12), Matthias Gesemann(5), Klaas Romanino(4), Nadine Cybulski(4), Lionel Tintignac(4), Alain J. Denzer(4), Dimitri Cloëtta(3), Filippo Oliveri(3), Pazit Polak(3), Herman van der Putten(3), Samuel Barbieri(3), Simone Danner(3), Maitea Guridi(3), Stephan Kröger(3), Gérard Escher(3), U.J. McMahan(3), Andrea Brancaccio(3), Beat Schumacher(3), Christoph Handschin(3)