Aidan J. Doherty

University of Sussex — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index9.2kcitations128works0.02yr avg
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Research Topics

DNA Repair Mechanisms(75), Bacterial Genetics and Biotechnology(32), DNA and Nucleic Acid Chemistry(32), CRISPR and Genetic Engineering(17), RNA and protein synthesis mechanisms(12)

Publications128 total

BPS2025 - Computational characterization of the molecular mechanism of DNA repair by mycobacterial primase-polymerase C
Biophysical Journal·2025
Coordination of Primer Initiation Within the Catalytic Domain of Human PrimPol
Journal of Molecular Biology·2023· 2 citedOpen Access
Mechanism of primer synthesis by Primase-Polymerases
Current Opinion in Structural Biology·2023· 15 citedOpen Access
Primase-polymerases: how to make a primer from scratch
Bioscience Reports·2023· 3 citedOpen Access
Reverse transcriptases prime DNA synthesis
Nucleic Acids Research·2023· 8 citedOpen Access
Molecular basis for the initiation of DNA primer synthesis
Nature·2022· 22 citedOpen Access
PLK1 regulates the PrimPol damage tolerance pathway during the cell cycle
Science Advances·2021· 22 citedOpen Access
CRISPR-Associated Primase-Polymerases are implicated in prokaryotic CRISPR-Cas adaptation
Nature Communications·2021· 13 citedOpen Access
Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication
Nucleic Acids Research·2021· 52 citedOpen Access
DNA repair | Nonhomologous End-Joining in Bacteria
Elsevier eBooks·2021
PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
Nature Communications·2020· 114 citedOpen Access
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
Nature Communications·2020· 10 citedOpen Access
Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro
Human Molecular Genetics·2020· 56 citedOpen Access
PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
2019· 12 citedOpen Access
PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching
PLoS ONE·2019· 26 citedOpen Access
PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells
Nucleic Acids Research·2019· 60 citedOpen Access
PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells
2018· 1 citedOpen Access
R‐loop formation during S phase is restricted by PrimPol‐mediated repriming
The EMBO Journal·2018· 99 citedOpen Access
The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction
Frontiers in Cellular Neuroscience·2018· 38 citedOpen Access
The involvement of tau in nucleolar transcription and the stress response
Acta Neuropathologica Communications·2018· 109 citedOpen Access
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Frequent Co-authors

Laura J. Bailey(10), Stephen P. Jackson(8), Thomas A. Guilliam(8), Penny A. Jeggo(7), Boris Kysela(7), R. S. Pitcher(7), Nigel C. Brissett(7), Stanisław K. Jóźwiakowski(5), Andrew Green(5), Geoffrey R. Weller(4), Julie Bianchi(4), Louise M. Tonkin(3), Sean G. Rudd(3), Benjamin A. Keen(3), Gavin C. Fox(3), Enriqueta Riballo(2), Marina Della(2), Fabrizio d’Adda di Fagagna(2), Richard P. Bowater(2), Elaine M. Taylor(2)