Jiro Takano

University of Tsukuba — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index3.5kcitations42works1.72yr avg
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Research Topics

Calpain Protease Function and Regulation(24), Alzheimer's disease research and treatments(10), Connexins and lens biology(7), Nerve injury and regeneration(6), RNA regulation and disease(6)

Publications42 total

Large scale eDNA database reveals potential for pseudo biodiversity
2025Open Access
Monocatechol metabolites of sesamin and episesamin promote higher autophagy flux compared to their unmetabolized forms by mTORC1-selective inhibition
Biochemical and Biophysical Research Communications·2025Open Access
Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells
Nutrients·2024· 5 citedOpen Access
Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration
Nature Communications·2019· 7 citedOpen Access
Tau binding protein CAPON induces tau aggregation and neurodegeneration
Nature Communications·2019· 103 citedOpen Access
Correction for Takano et al., “Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival”
Molecular and Cellular Biology·2018· 1 citedOpen Access
Expression of Concern for Takano et al., “Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival”
Molecular and Cellular Biology·2017Open Access
Leukocyte Calpain Deficiency Reduces Angiotensin II–Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice
Arteriosclerosis Thrombosis and Vascular Biology·2016· 36 citedOpen Access
Abstract 465: Inducible Depletion of Calpain-2 Attenuates Angiotensin II-induced Abdominal Aortic Aneurysms in Male LDL Receptor Deficient Mice
Arteriosclerosis Thrombosis and Vascular Biology·2015
Abstract 587: Leukocyte Calpain Deficiency Reduces Angiotensin II-induced Inflammation and Atherosclerosis in Hypercholesterolemic Mice
Arteriosclerosis Thrombosis and Vascular Biology·2015
Involvement of calpains in adult neurogenesis: implications for stroke
Frontiers in Cellular Neuroscience·2015· 34 citedOpen Access
Roles of calpain-1 and calpain-2 in muscular homeostasis
Confit Support·2014
Calpain-dependent Cleavage of N-cadherin Is Involved in the Progression of Post-myocardial Infarction Remodeling
Journal of Biological Chemistry·2014· 51 citedOpen Access
Single App knock-in mouse models of Alzheimer's disease
Nature Neuroscience·2014· 1.3k cited
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice
Human Molecular Genetics·2014· 107 citedOpen Access
Calpastatin Prevents NF-κB–Mediated Hyperactivation of Macrophages and Attenuates Colitis
The Journal of Immunology·2013· 32 citedOpen Access
Loss of DARPP-32 and calbindin in multiple system atrophy
Journal of Neural Transmission·2013· 15 citedOpen Access
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology
Nature Communications·2012· 167 citedOpen Access
Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor
Neurobiology of Disease·2012· 59 citedOpen Access
P1‐279: APP knock‐in mouse: A novel and more relevant model mouse for Alzheimer's disease
Alzheimer s & Dementia·2012
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Frequent Co-authors

Takaomi C. Saido(36), Nobuhisa Iwata(20), Takashi Saito(10), Naomi Mihira(10), Yukio Matsuba(9), Takahiro Suemoto(8), Makoto Higuchi(5), Athar H. Chishti(5), Per Nilsson(4), Masaki Nishimura(4), Masatoshi Maki(4), Shigeyoshi Itohara(3), Morin Ryu(3), Masayuki Yasuda(3), Ahmed Y. Shanab(3), Noriko Himori(3), Toru Nakazawa(3), Ryo Fujioka(3), Emi Hosoki(3), Deborah A. Howatt(3)