Michael R. Kuehn

German Cancer Research Center — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index7.5kcitations77works0.02yr avg
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Research Topics

Developmental Biology and Gene Regulation(20), Congenital heart defects research(15), Pluripotent Stem Cells Research(12), Ubiquitin and proteasome pathways(9), CRISPR and Genetic Engineering(8)

Publications77 total

Menin-Inhibition Sensitizes Acute Myeloid Leukemia to CLEC12A-Directed CAR Cell Therapy
2026Open Access
The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax
Blood·2022· 1 cited
Solar Concepts for Building
2018
An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL-Rearranged Leukemia to DOT1L Inhibition
Blood·2016
SENP1-modulated sumoylation regulates retinoblastoma protein (RB) and Lamin A/C interaction and stabilization
Oncogene·2016· 20 cited
Inhibiting Smad2/3 signaling in pluripotent mouse embryonic stem cells enhances endoderm formation by increasing transcriptional priming of lineage‐specifying target genes
Developmental Dynamics·2016· 3 citedOpen Access
leads to embryonic lethal mutation (Mov-13 mice/insertional mutagenesis/sequence of al(I) collagen gei
2016
Time requirements of alkali vs. NID plasmid minipreps.
Figshare·2015Open Access
Nodal signaling from the visceral endoderm is required to maintain Nodal gene expression in the epiblast and drive DVE/AVE migration
Developmental Biology·2014· 38 citedOpen Access
Abstract A15: The landscape of somatic mutations in the core-binding factor acute myeloid leukemias
Cancer Research·2014
Isolation of rare recombinants without using selectable markers for one-step seamless BAC mutagenesis
Nature Methods·2014· 11 citedOpen Access
Loss of function of mouse Pax‐Interacting Protein 1‐associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development
Developmental Dynamics·2014· 23 citedOpen Access
Polycomb Determines Responses to Smad2/3 Signaling in Embryonic Stem Cell Differentiation and in Reprogramming
Stem Cells·2013· 9 citedOpen Access
Senp1 Is Essential for Desumoylating Sumo1-Modified Proteins but Dispensable for Sumo2 and Sumo3 Deconjugation in the Mouse Embryo
Cell Reports·2013· 58 citedOpen Access
Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning
Developmental Biology·2013· 26 citedOpen Access
A novel approach to isolate unselected recombinants facilitates markerless DNA recombineering
The FASEB Journal·2012
Differentiating frequency of recombination from frequency of recombinants
The FASEB Journal·2012
A One-Step Miniprep for the Isolation of Plasmid DNA and Lambda Phage Particles
PLoS ONE·2011· 28 citedOpen Access
Hofmeister series salts enhance purification of plasmid DNA by non‐ionic detergents
Biotechnology and Bioengineering·2011· 11 cited
Nodal Signaling Recruits the Histone Demethylase Jmjd3 to Counteract Polycomb-Mediated Repression at Target Genes
Science Signaling·2010· 117 citedOpen Access
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Frequent Co-authors

Linda A. Lowe(10), Prashant Sharma(8), Amit Kumar(6), Margaret Lualdi(5), Satoru Yamada(4), Allan Bradley(3), Martin Evans(3), Christopher V.E. Wright(3), Rodolfo Murillas(3), Norman Arnheim(3), Michael Levin(2), Elizabeth J. Robertson(2), Xunlei Zhou(2), Brigid L.M. Hogan(2), Dorothy M. Supp(2), S. Steven Potter(2), Shai Izraeli(2), Virginia Bertness(2), Ilan R. Kirsch(2), Evgenij Evdokimov(2)