Casper C. Hoogenraad

Gene Therapy Laboratory — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

94h-index31.4kcitations310works11.12yr avg
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Research Topics

Microtubule and mitosis dynamics(137), Cellular transport and secretion(98), Neuroscience and Neuropharmacology Research(47), Cellular Mechanics and Interactions(41), Ubiquitin and proteasome pathways(28)

Publications309 total

Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration
npj Drug Discovery.·2025· 4 citedOpen Access
CSF proteomics of semorinemab Alzheimer’s disease trials identifies cell-type specific signatures
Brain·2025· 1 cited
Secreted neurofilament light chain after neuronal damage induces myeloid cell activation and neuroinflammation
Cell Reports·2025· 17 citedOpen Access
The dynamic axon initial segment: From neuronal polarity to network homeostasis
Neuron·2025· 17 citedOpen Access
Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology
Alzheimer s & Dementia·2024· 10 citedOpen Access
Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation
Cell Reports Methods·2024· 24 citedOpen Access
SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation
2024· 9 citedOpen Access
Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions
Developmental Cell·2024· 34 citedOpen Access
Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons
Journal of Neuroscience·2024· 9 citedOpen Access
Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer’s disease pathophysiology
2024· 1 citedOpen Access
CSF proteomic analysis of semorinemab Ph2 trials in prodromal-to-mild (Tauriel) and mild-to-moderate (Lauriet) Alzheimer’s disease identifies distinct trial cell-type specific proteomic signatures
2024· 2 citedOpen Access
A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity
Cell Reports Methods·2024· 5 citedOpen Access
TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models
iScience·2023· 7 citedOpen Access
Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release
Nature Communications·2023· 45 citedOpen Access
Sodium channel endocytosis drives axon initial segment plasticity
Science Advances·2023· 34 citedOpen Access
Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering
ACS Nano·2023· 84 citedOpen Access
Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection
Molecular Therapy — Nucleic Acids·2023· 27 citedOpen Access
Supplementary code, raw data and figure plots from "Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells"
Figshare·2023Open Access
Axonal ER tubules regulate local translation via P180/RRBP1-mediated ribosome interactions
2022· 4 citedOpen Access
PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites
PLoS Biology·2022· 16 citedOpen Access
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Frequent Co-authors

Anna Akhmanova(23), Lukas C. Kapitein(17), Ilya Grigoriev(10), Jeroen Demmers(9), Phebe S. Wulf(8), Niels Galjart(7), Eugene A. Katrukha(7), Morgan Sheng(6), Chris I. De Zeeuw(6), Frank Grosveld(6), Max A. Schlager(5), Nanda Keijzer(5), Dick Jaarsma(5), Michel O. Steinmetz(5), Bjorn Dortland(4), Jacek Jaworski(4), Daniël Splinter(4), R. Jeroen Pasterkamp(4), Т. Ф. Степанова(3), Gideon Lansbergen(3)