Gerald D. Frank

Vanderbilt University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index3.3kcitations54works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(19), Renin-Angiotensin System Studies(15), Receptor Mechanisms and Signaling(12), Nitric Oxide and Endothelin Effects(10), Cytokine Signaling Pathways and Interactions(8)

Publications54 total

Promyelocytic Leukemia Zinc Finger Protein Activates GATA4 Transcription and Mediates Cardiac Hypertrophic Signaling from Angiotensin II Receptor 2
PLoS ONE·2012· 44 citedOpen Access
p21-Activated Kinase 1 Participates in Vascular Remodeling In Vitro and In Vivo
Hypertension·2009· 28 citedOpen Access
Abstract 5687: Identification of HGF as a Novel Vascular ADAM Metalloprotease Substrate by Phage Display
Circulation·2009
Endothelial Nitric Oxide Synthase Inhibits G<sub>12/13</sub>and Rho-Kinase Activated by the Angiotensin II Type-1 Receptor
Arteriosclerosis Thrombosis and Vascular Biology·2008· 39 citedOpen Access
Abstract 1703: Involvement of Adam17 in Neointima Formation after Vascular Injury; Potential Role of Tyrosine Phosphorylation on its Activity
Circulation·2008
Central Role of G<sub>q</sub>in the Hypertrophic Signal Transduction of Angiotensin II in Vascular Smooth Muscle Cells
Endocrinology·2008· 48 citedOpen Access
Novel Role of Protein Kinase C-δ Tyr<sup>311</sup>Phosphorylation in Vascular Smooth Muscle Cell Hypertrophy by Angiotensin II
Hypertension·2008· 32 citedOpen Access
Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology
Clinical Science·2007· 423 cited
Distinct G proteins mediate the EGFR transactivation pathway and the Rho/Rho‐kinase (ROCK) pathway activated by angiotensin II in vascular smooth muscle cells.
The FASEB Journal·2007
Activation of Endothelial Nitric Oxide Synthase by the Angiotensin II Type 1 Receptor
Endocrinology·2006· 47 citedOpen Access
ADAM17 Mediates Epidermal Growth Factor Receptor Transactivation and Vascular Smooth Muscle Cell Hypertrophy Induced by Angiotensin II
Arteriosclerosis Thrombosis and Vascular Biology·2006· 45 citedOpen Access
Angiotensin II Signal Transduction Through Small GTP-Binding Proteins
Hypertension·2006· 93 cited
ADAM17 Mediates Epidermal Growth Factor Receptor Transactivation and Vascular Smooth Muscle Cell Hypertrophy Induced by Angiotensin II
Arteriosclerosis Thrombosis and Vascular Biology·2006· 137 citedOpen Access
Antagonism or Synergism
Journal of Biological Chemistry·2006· 35 citedOpen Access
Current Understanding of the Mechanism and Role of ROS in Angiotensin II Signal Transduction
Current Pharmaceutical Biotechnology·2006· 19 cited
Growth stimulating and inhibitory signals of angiotensin II type 2 receptor are mediated by PLZF and SHP‐1
The FASEB Journal·2006
Coordinated regulation of epidermal Growth Factor Signaling by the protein tyrosine phosphatases SHP‐1 and SHP‐2
The FASEB Journal·2006
PDGF induces a ROS and Src kinase‐dependent PKC‐delta Tyr‐311 phosphorylation promoting vascular smooth muscle cell growth and proliferation
The FASEB Journal·2006· 1 cited
Angiotensin II Regulates Vascular and Endothelial Dysfunction: Recent Topics of Angiotensin II Type-1 Receptor Signaling in the Vasculature
Current Vascular Pharmacology·2005· 138 cited
Redox-Dependent Protein Kinase Regulation by Angiotensin II: Mechanistic Insights and Its Pathophysiology
Antioxidants and Redox Signaling·2005· 63 cited
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Frequent Co-authors

Satoru Eguchi(40), Tadashi Inagami(24), Evangeline D. Motley(21), Kunie Eguchi(13), Haruhiko Ohtsu(12), Sadaharu Higuchi(10), Hiroyuki Suzuki(10), Peter J. Dempsey(8), Hirotoshi Utsunomiya(8), Mizuo Mifune(8), H. Nakashima(7), Shuichi Saito(6), Akinari Hinoki(6), Eugen Brailoiu(5), Motoi Ohba(5), Heigoro Shirai(4), Terukatsu Sasaki(4), Ning Wang(4), Ronghua Ding(4), Takaaki Senbonmatsu(4)