David J. Ponting

Environmental Science · Physical Sciences

19h-index977citations49works5.32yr avg
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Research Topics

Water Treatment and Disinfection(17), Computational Drug Discovery Methods(12), Carcinogens and Genotoxicity Assessment(9), Sulfur Compounds in Biology(9), Contact Dermatitis and Allergies(8)

Publications49 total

Ames concordance with the in vivo transgenic rodent (TGR) gene mutation assay for NDSRIs and relative in vivo TGR potency with nitrosamines with robust dose-response carcinogenicity data
Regulatory Toxicology and Pharmacology·2026· 1 cited
Establishing best practice for N-nitrosamine read-across and surrogate selection
Regulatory Toxicology and Pharmacology·2025
Computational mechanistic study on N-nitrosation reaction of secondary amines
Journal of Molecular Modeling·2025
P18-78 What does new nitrosamine data reveal about the CPCA framework?
Toxicology Letters·2025
Computational Mechanistic Study on N-Nitrosation Reaction of Secondary Amines
2025Open Access
Evaluating the lifetime cumulative dose as a basis for carcinogenic potency of nitrosamines – a key tenet underpinning less-than-lifetime approaches for establishing acceptable intake limits
Regulatory Toxicology and Pharmacology·2025· 4 citedOpen Access
Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds
Archives of Toxicology·2025· 3 citedOpen Access
Control of N-nitrosamine impurities in drug products: Progressing the current CPCA framework and supporting the derivation of robust compound specific acceptable intakes
Regulatory Toxicology and Pharmacology·2024· 11 citedOpen Access
Industrial Genotoxicology Group: 36th Annual Meeting Report
Mutagenesis·2024
Bioactivation of cinnamic alcohol in a reconstructed human epidermis model and evaluation of sensitizing potency of the identified metabolites
Frontiers in Toxicology·2024· 3 citedOpen Access
From quantum mechanics to metabolism pathways
Drug Metabolism and Pharmacokinetics·2024
Latest developments in nitrosamine structure-activity relationships for carcinogenicity
Drug Metabolism and Pharmacokinetics·2024
A Case to Support the Continued Use of Rifampin in Clinical Drug–Drug Interaction Studies
Clinical Pharmacology & Therapeutics·2024· 2 cited
<i>In Silico</i> Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth
Organic Process Research & Development·2024· 14 citedOpen Access
Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency
Chemical Research in Toxicology·2024· 43 cited
Developing and validating read-across workflows that enable decision making for toxicity and potency: Case studies with N-nitrosamines
Computational Toxicology·2024· 4 cited
Use of the TD50 99 % CI for single dose rodent carcinogenicity studies
Toxicology Letters·2023· 2 cited
Revisiting the Landscape of Potential Small and Drug Substance Related Nitrosamines in Pharmaceuticals
Journal of Pharmaceutical Sciences·2023· 27 citedOpen Access
Nitrosamine acceptable intakes should consider variation in molecular weight: The implication of stoichiometric DNA damage
Regulatory Toxicology and Pharmacology·2023· 15 citedOpen Access
P24-15: How are pre-competitive data sharing initiatives in the pharmaceutical industry aiding in compiling nitrosamine risk assessments
Toxicology Letters·2023
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Frequent Co-authors

Robert Thomas(12), Rachael E. Tennant(8), Andrew Thresher(6), Robert S. Foster(6), Joerg Schlingemann(6), Ida B. Niklasson(6), Kristina Luthman(6), Ann‐Therése Karlberg(6), Michael J. Burns(5), G. Smith(5), Stéphanie Simon(5), Andreas Czich(5), Peter Hunt(5), Matthew Segall(5), Joel P. Bercu(5), Grace Kocks(4), Isabella Karlsson(4), George E. Johnson(4), Mario Öeren(4), Kevin P. Cross(3)