Giuseppe Giannini

Alfasigma (Italy) — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index3.6kcitations128works6.82yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(25), Peptidase Inhibition and Analysis(22), Proteoglycans and glycosaminoglycans research(12), Click Chemistry and Applications(12), Chemical Synthesis and Analysis(11)

Publications128 total

SGSS05-NS3, a covalent SETD8 inhibitor that activates p53 pathway in neuroblastoma
Journal of Experimental & Clinical Cancer Research·2025Open Access
Drug enteric metabolism in gut microbiota-brain crosstalk
Life Sciences·2025Open Access
A mixture of postbiotics/tyndallized probiotics reduces trimethylamine (TMA) in trimethylaminuria models: Evidence from in vitro and in vivo studies
Frontiers in Pharmacology·2025· 1 citedOpen Access
Fluoromethylcarnitine, a novel inhibitor of trimethylamine levels in trimethylaminuria and trimethylamine N-oxide related disorders
European Journal of Medicinal Chemistry·2025Open Access
C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation
Molecular Cancer·2025· 14 citedOpen Access
Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction
Frontiers in Immunology·2025· 25 citedOpen Access
Exploring Trimethylaminuria: Genetics and Molecular Mechanisms, Epidemiology, and Emerging Therapeutic Strategies
Biology·2024· 3 citedOpen Access
A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides
Chemical Science·2024· 11 citedOpen Access
Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Gum Diseases
Gels·2023Open Access
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth
Pharmacological Research·2023· 26 citedOpen Access
Tau-Marin Mucoadhesive Gel for Prevention and Treatment of Periodontal Diseases
Preprints.org·2023· 2 citedOpen Access
Synthesis and Biological Characterisation of a New Prodrug Based on Aza-Quinone Methide Reactivity for the Release of a Thiol-Containing Hdac Inhibitor
SSRN Electronic Journal·2023Open Access
Metal-organic frameworks (MOFs) as biomolecules drug delivery systems for anticancer purposes
European Journal of Medicinal Chemistry·2022· 88 citedOpen Access
Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor
International Journal of Molecular Sciences·2022· 6 citedOpen Access
Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening
ACS Medicinal Chemistry Letters·2022· 8 citedOpen Access
Probiotics‐Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases
International Journal of Dentistry·2022· 15 citedOpen Access
Antibody drug conjugates with hydroxamic acid cargos for histone deacetylase (HDAC) inhibition
Chemical Communications·2021· 13 citedOpen Access
Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents
ACS Medicinal Chemistry Letters·2020· 19 citedOpen Access
ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1
Frontiers in Oncology·2020· 18 citedOpen Access
New classes of potent heparanase inhibitors from ligand-based virtual screening
Journal of Enzyme Inhibition and Medicinal Chemistry·2020· 16 citedOpen Access
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Frequent Co-authors

Claudio Pisano(25), Loredana Vesci(17), Walter Cabri(13), Sergio Penco(11), Ferdinando Maria Milazzo(11), Massimo Castorina(10), Gianfranco Battistuzzi(10), Sabrina Dallavalle(10), Paolo Carminati(8), Maurizio Taddei(7), Loana Musso(7), Daniele Simoni(6), Riccardo Rondanin(6), Riccardo Baruchello(6), Domenico Alloatti(6), Mario B. Guglielmi(6), Marcella Barbarino(6), Grazia Gallo(6), Lucio Merlini(6), Valentina Zuco(6)