Cristina Alonso‐Alija

Bayer (United States) — United States

Medicine · Health Sciences

14h-index1.7kcitations33works0.02yr avg
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Research Topics

Nitric Oxide and Endothelin Effects(12), Synthesis and Biological Evaluation(6), Receptor Mechanisms and Signaling(5), Crystallization and Solubility Studies(5), X-ray Diffraction in Crystallography(5)

Publications33 total

Nitric Oxide-independent Activation of Soluble Guanylate Cyclase by BAY 60-2770 in Experimental Liver Fibrosis
Arzneimittelforschung·2011· 92 cited
Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension
BMC Pharmacology·2009· 2 citedOpen Access
Cover Picture: Discovery of Riociguat (BAY 63‐2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension (ChemMedChem 5/2009)
ChemMedChem·2009Open Access
Discovery of Riociguat (BAY 63‐2521): A Potent, Oral Stimulator of Soluble Guanylate Cyclase for the Treatment of Pulmonary Hypertension
ChemMedChem·2009· 181 cited
Design and synthesis of the first NO- and haem-independent sGC activator BAY 58–2667 for the treatment of acute decompensated heart failure
BMC Pharmacology·2007· 4 citedOpen Access
Efficient Synthesis of 6‐Amino‐Substituted Pyridin‐2(1H)‐ones Using in situ Generated Propiolic Acid Chloride.
ChemInform·2006
Efficient Regioselective Synthesis of 6‐Amino‐5‐benzoyl‐1‐Substituted 2(1H)‐Pyridinones.
ChemInform·2006Open Access
CCDC 273344: Experimental Crystal Structure Determination
The Cambridge Structural Database·2006Open Access
Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1<i>H</i>)-Pyridinones
The Journal of Organic Chemistry·2005· 52 cited
Antifibrotic effects of an sGC activator in rat models of liver fibrosis
BMC Pharmacology·2005· 3 citedOpen Access
A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway
Analytical Biochemistry·2005· 58 cited
Efficient Synthesis of 6-Amino-Substituted Pyridin-2(1<i>H</i>)-ones Using in situ Generated Propiolic Acid Chloride
Synthesis·2005· 19 cited
A Convenient Synthesis of 4‐Alkoxy‐ and 4‐Hydroxy‐2,6‐difluoroanilines.
ChemInform·2004
A convenient synthesis of 4-alkoxy- and 4-hydroxy-2,6-difluoroanilines
Tetrahedron Letters·2003· 13 cited
An automated aequorin luminescence-based functional assay used to identify BAY 58-2667, a new NO-independent soluble guanylate cyclase activator
BMC News and views·2003
CCDC 157014: Experimental Crystal Structure Determination
The Cambridge Structural Database·2003Open Access
CCDC 157015: Experimental Crystal Structure Determination
The Cambridge Structural Database·2003Open Access
NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle
British Journal of Pharmacology·2002· 308 citedOpen Access
ChemInform Abstract: A Novel Approach to Amidines from Esters.
ChemInform·2002
A novel approach to amidines from esters
Tetrahedron Letters·2002· 18 cited
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Frequent Co-authors

Johannes‐Peter Stasch(11), Alexander Straub(10), Hartmut Schirok(10), Frank Wunder(9), Achim Feurer(7), Jordi Benet‐Buchholz(7), Gary A. Molander(6), Martin Michels(6), Elke Stahl(5), Helmut Gröner(5), Heiner Apeler(4), Torsten Minuth(4), Matthias Schramm(4), Joachim Mittendorf(4), Karl‐Heinz Schlemmer(4), Bernhard Ducke(4), Klaus Dembowsky(3), Elisabeth Perzborn(3), H. Schröder(3), Werner Schroeder(3)