Lei L. Chen

The University of Texas MD Anderson Cancer Center — United States

Medicine · Health Sciences

14h-index3.4kcitations20works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Gastrointestinal Tumor Research and Treatment(13), Sarcoma Diagnosis and Treatment(8), Gastric Cancer Management and Outcomes(4), Immune Cell Function and Interaction(3), Chronic Myeloid Leukemia Treatments(3)

Publications20 total

SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions
PLoS ONE·2017· 5 citedOpen Access
Exploiting anti-tumor immunity to overcome relapse and improve remission duration
2013
Combining targeted therapy with immunotherapy (interferon-α)
OncoImmunology·2012· 12 citedOpen Access
Exploiting antitumor immunity to overcome relapse and improve remission duration
Cancer Immunology Immunotherapy·2011· 47 citedOpen Access
Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression
Modern Pathology·2008· 38 cited
Clinical, histopathologic, molecular and therapeutic findings in a large kindred with gastrointestinal stromal tumor
International Journal of Cancer·2007· 77 citedOpen Access
We Should Desist Using RECIST, at Least in GIST
Journal of Clinical Oncology·2007· 551 cited
Correlation of Computed Tomography and Positron Emission Tomography in Patients With Metastatic Gastrointestinal Stromal Tumor Treated at a Single Institution With Imatinib Mesylate: Proposal of New Computed Tomography Response Criteria
Journal of Clinical Oncology·2007· 1.5k citedOpen Access
Surgical Resection of Gastrointestinal Stromal Tumors After Treatment with Imatinib
Annals of Surgical Oncology·2006· 268 cited
Imatinib resistance in gastrointestinal stromal tumors
Current Oncology Reports·2005· 44 cited
A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors
Oncogene·2005· 45 citedOpen Access
KIT/Val654Ala receptor detected in one imatinib-resistant GIST patient [3] (multiple letters)
2005
A Missense Mutation in KIT Kinase Domain 1 Correlates with Imatinib Resistance in Gastrointestinal Stromal Tumors
Cancer Research·2004· 341 cited
A two‐arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas
Cancer·2003· 124 citedOpen Access
Is there a role for surgery in patients with “unresectable” cKIT+ gastrointestinal stromal tumors treated with imatinib mesylate?
The American Journal of Surgery·2003· 138 cited
Extraosseous Osteosarcoma: Response to Treatment and Long-Term Outcome
Journal of Clinical Oncology·2002· 76 cited
Cytokine Regulation of Gelatinase Production by Head and Neck Squamous Cell Carcinoma: The Role of Tumor Necrosis Factor-Alpha
Annals of Otology Rhinology & Laryngology·1995· 44 cited
Removal of fibroblasts from primary cultures of squamous cell carcinoma of the head and neck
Methods in Cell Science·1993· 9 cited
Cytokine expression by head and neck squamous cell carcinomas
The American Journal of Surgery·1992· 99 cited
Synthesis and secretion of albumin by a synchronized rat hepatoma cell line
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis·1977· 7 cited

Frequent Co-authors

Robert S. Benjamin(13), Shreyaskumar Patel(9), Haesun Choi(7), Jonathan C. Trent(7), Marsha L. Frazier(7), Kelly K. Hunt(5), Barry W. Feig(5), Robert H.I. Andtbacka(5), Homer A. Macapinlac(4), Elsie F. Wu(4), Víctor G. Prieto(4), Raphael E. Pollock(4), Courtney L. Scaife(4), Michael A. Burgess(3), M. A. Burgess(3), Peter W. T. Pisters(3), Eric Mann(3), Jeffrey D. Spiro(3), Launce Gouw(3), Mahyar Sabripour(3)