Todd J. Zahn

Duquesne University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index201citations13works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(7), Biochemical and Molecular Research(4), Enzyme Structure and Function(3), Plant biochemistry and biosynthesis(3), Protein Structure and Dynamics(2)

Publications13 total

Computational and Conformational Evaluation of FTase Alternative Substrates: Insight into a Novel Enzyme Binding Pocket.
ChemInform·2005
Interplay of Isoprenoid and Peptide Substrate Specificity in Protein Farnesyltransferase
Biochemistry·2005· 24 cited
Computational and Conformational Evaluation of FTase Alternative Substrates:  Insight into a Novel Enzyme Binding Pocket
Journal of Chemical Information and Modeling·2005· 8 cited
ChemInform Abstract: Synthesis and Evaluation of GGPP Geometric Isomers: Divergent Substrate Specificities of FTase and GGTase I.
ChemInform·2001
Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I
Bioorganic & Medicinal Chemistry Letters·2001· 20 citedOpen Access
ChemInform Abstract: Grignard‐Mediated Synthesis and Preliminary Biological Evaluation of Novel 3‐Substituted Farnesyl Diphosphate Analogues.
ChemInform·2000
Grignard-mediated synthesis and preliminary biological evaluation of novel 3-substituted farnesyl diphosphate analogues
Bioorganic & Medicinal Chemistry Letters·2000· 20 citedOpen Access
Evaluation of Isoprenoid Conformation in Solution and in the Active Site of Protein-Farnesyl Transferase Using Carbon-13 Labeling in Conjunction with Solution- and Solid-State NMR
Journal of the American Chemical Society·2000· 26 cited
Novel Farnesol and Geranylgeraniol Analogues:  A Potential New Class of Anticancer Agents Directed against Protein Prenylation
Journal of Medicinal Chemistry·1999· 62 citedOpen Access
Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors
Bioorganic & Medicinal Chemistry·1999· 31 cited
Synthesis and biological evaluation of 3-substituted farnesyl diphosphate analogs with synthesis and conformational analysis of bis-carbon-13 labeled FPP analogs
Human Biology·1999
ChemInform Abstract: Synthesis and Conformational Analysis of Di‐<sup>13</sup>C‐Labeled Farnesyl Diphosphate Analogues
ChemInform·1998
Synthesis and conformational analysis of di-13C-labeled farnesyl diphosphate analogs
Tetrahedron Letters·1998· 10 cited

Frequent Co-authors

Richard A. Gibbs(8), Richard A. Gibbs(4), Carolyn Weinbaum(4), Mohamad B. Ksebati(3), Barbara S. Gibbs(2), Judith S. Sebolt–Leopold(2), Jessica Whitney(2), Brian Henriksen(2), Jeffrey D. Evanseck(2), Steven M. Firestine(2), YongQi Mu(1), Jeffrey T. Eummer(1), Markus Eilers(1), Zhengmao Guo(1), Matthew P. Simon(1), Jeffrey D. Scholten(1), Steven O. Smith(1), Sarah A. Reigard(1), Kellie B. Haworth(1), Katherine A. Hicks(1)