Ian Churcher

Amicus Therapeutics (United Kingdom) — United Kingdom

Computer Science · Physical Sciences

29h-index5.7kcitations75works10.72yr avg
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Research Topics

Computational Drug Discovery Methods(14), Alzheimer's disease research and treatments(12), Crystallization and Solubility Studies(12), Cholinesterase and Neurodegenerative Diseases(12), Protein Degradation and Inhibitors(12)

Publications75 total

Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9
Nature Communications·2025· 6 citedOpen Access
Return to Flatland
Nature Reviews Chemistry·2025· 24 cited
Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept
2025· 2 cited
Optimization of a Series of RIPK2 PROTACs
Journal of Medicinal Chemistry·2021· 65 citedOpen Access
The rise and rise of protein degradation: Opportunities and challenges ahead
Drug Discovery Today·2021· 73 citedOpen Access
Structural Insights into PROTAC-Mediated Degradation of Bcl-xL
ACS Chemical Biology·2020· 86 cited
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
Communications Biology·2020· 209 citedOpen Access
Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
ACS Chemical Biology·2018· 173 cited
Organic synthesis provides opportunities to transform drug discovery
Nature Chemistry·2018· 1.4k cited
CCDC 1008924: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
CCDC 1008922: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
CCDC 1008923: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
Journal of Medicinal Chemistry·2017· 449 citedOpen Access
Synthesis and Demonstration of the Biological Relevance of sp<sup>3</sup>‐rich Scaffolds Distantly Related to Natural Product Frameworks
Chemistry - A European Journal·2017· 62 citedOpen Access
Abstract S4-03: Targeted and selective degradation of estrogen receptor (ER) alpha by PROTACs
Cancer Research·2017
CCDC 1526780: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1526777: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1526778: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
CCDC 1526779: Experimental Crystal Structure Determination
The Cambridge Structural Database·2017Open Access
ChemInform Abstract: Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines.
ChemInform·2016
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Frequent Co-authors

Dirk Beher(7), Mark S. Shearman(7), Earl E. Clarke(6), Jonathan D.J. Wrigley(6), Huw D. Lewis(6), Robert A. Stockman(6), William Lewis(5), Afjal H. Miah(4), John D. Harling(4), Alan Nadin(4), Michael Reilly(4), Richard G. Doveston(4), Adam Nelson(4), Timothy Harrison(4), Toni Moragas(4), Alina Mares(3), Ian E. Smith(3), Bartholomew J. Votta(3), Paul S. Carter(3), Channa K. Hattotuwagama(3)