Alan T. Savitz

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Neuroscience · Life Sciences

9h-index422citations15works2.02yr avg
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Research Topics

Sleep and Wakefulness Research(9), Circadian rhythm and melatonin(7), Sleep and related disorders(6), Bone health and treatments(3), Bone health and osteoporosis research(2)

Publications15 total

Assessment of an orexin-2 receptor (OX2R) PET tracer feasibility: [18F]A in vitro brain tissue based binding assay and in vivo PET imaging study
Nuclear Medicine and Biology·2025
Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus
Pain·2024· 4 citedOpen Access
341 Acute effects of seltorexant, a selective orexin-2 antagonist (JNJ- 42847922), on driving after bedtime administration
SLEEP·2021· 1 citedOpen Access
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2017· 8 citedOpen Access
Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys
SLEEP·2016· 45 citedOpen Access
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties
Bioorganic & Medicinal Chemistry Letters·2015· 20 citedOpen Access
Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs
Frontiers in Behavioral Neuroscience·2014· 37 citedOpen Access
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
BMC Neuroscience·2013· 93 citedOpen Access
Effect of odanacatib on bone turnover markers, bone density and geometry of the spine and hip of ovariectomized monkeys: A head-to-head comparison with alendronate
Bone·2013· 37 cited
High-resolution peripheral quantitative computed tomography and finite element analysis of bone strength at the distal radius in ovariectomized adult rhesus monkey demonstrate efficacy of odanacatib and differentiation from alendronate
Bone·2013· 35 cited
Quantitative Electroencephalography Within Sleep/Wake States Differentiates GABAA Modulators Eszopiclone and Zolpidem From Dual Orexin Receptor Antagonists in Rats
Neuropsychopharmacology·2013· 37 citedOpen Access
Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition
Science Translational Medicine·2013· 89 cited
Pharmacological Validation of Candidate Causal Sleep Genes Identified in an N2 Cross
Journal of Neurogenetics·2011· 12 cited
Head-to-head comparison of treatment effects of odanacatib to alendronate in the ovariectomized rhesus monkey: A longitudinal multi-modality imaging study
Bone·2011· 2 cited
HR-pQCT based finite element analysis estimates of bone strength at ultra-distal radius in ovariectomized rhesus monkeys demonstrates efficacy of odanacatib and differentiation from Alendronate
Bone·2011· 2 cited

Frequent Co-authors

Anthony L. Gotter(8), Christopher J. Winrow(8), John J. Renger(8), Susan L. Garson(7), Steven V. Fox(7), Pamela L. Tannenbaum(7), Scott D. Kuduk(7), Paul J. Coleman(7), Joanne Stevens(6), Spencer J. Tye(6), Jason M. Uslaner(6), Richard Hargreaves(5), Joseph Brunner(4), Jacquelyn Binns(4), Terrence P. McDonald(4), Donald S. Williams(4), Paul J. McCracken(4), Parker D. Mathers(4), John Szumiloski(4), Richa Y. Jayakar(4)