Ruth Ruddle

Institute of Cancer Research — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index1.7kcitations181works2.92yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(26), Cancer-related gene regulation(23), Ovarian cancer diagnosis and treatment(22), Computational Drug Discovery Methods(21), Lung Cancer Treatments and Mutations(21)

Publications181 total

Table 2 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma
2025Open Access
Figure 3 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma
2025Open Access
Figure 5 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma
2025Open Access
Table 1 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma
2025Open Access
Figure 1 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma
2025Open Access
Figure 2 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma
2025Open Access
Figure 4 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma
2025Open Access
Supplementary Figures S1-S3 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma
2025Open Access
Figure 3 from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
2025Open Access
Figure 6 from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
2025Open Access
Figure 4 from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
2025Open Access
Figure 1 from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
2025Open Access
Figure 5 from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
2025Open Access
Figure 2 from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes
2025Open Access
EXTH-93. Combination of ALK2 and cholesterol targeting agents exploits linked genetic and metabolic dependencies in diffuse midline glioma
Neuro-Oncology·2025Open Access
Defactinib with avutometinib in patients with solid tumors: the phase 1 FRAME trial
Nature Medicine·2025· 15 citedOpen Access
85P: Phase I results from the phase I/II POTENT trial of tepotinib and pembrolizumab in non-small cell lung cancer (NSCLC)
Journal of Thoracic Oncology·2025· 1 citedOpen Access
FRAME: A phase I trial of defactinib (FAK inhibitor) in combination with avutometinib (RAF-MEK clamp) in patients with solid tumours including low grade serous ovarian cancer
2024Open Access
GABAergic neuronal lineage development determines clinically actionable targets in diffuse hemispheric glioma, H3G34-mutant
Cancer Cell·2024· 40 citedOpen Access
DIPG-22. A NOVEL ROLE FOR ACVR1/ALK2 IN REGULATING CHOLESTEROL BIOSYNTHESIS PROVIDES A NEW COMBINATORIAL THERAPEUTIC APPROACH FOR PATIENTS WITH DMG
Neuro-Oncology·2024Open Access
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Frequent Co-authors

Florence I. Raynaud(46), Udai Banerji(26), Johann S. de Bono(21), Karen E. Swales(15), Mona Parmar(13), Nina Tunariu(13), Paul Workman(13), Alison Turner(12), Emma Hall(12), Anna Minchom(11), Suzanne Carreira(10), Vasiliki Michalarea(9), Ruth Riisnaes(9), Susana Banerjee(9), Melanie Valenti(8), Suzanne A. Eccles(8), Shaun Decordova(8), Bristi Basu(8), Juanita Lopez(8), Wynne Aherne(8)