Javier Casas

Universidad de Valladolid — Spain

Immunology and Microbiology · Life Sciences

18h-index1.3kcitations30works5.82yr avg
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Research Topics

T-cell and B-cell Immunology(7), Immune Cell Function and Interaction(6), Protein Kinase Regulation and GTPase Signaling(4), Lipid metabolism and biosynthesis(4), Ion Channels and Receptors(3)

Publications30 total

PKCϵ-mediated phosphorylation of TRPC3 channel at S712 is essential for its inactivation during inflammatory signaling
Frontiers in Immunology·2026Open Access
Spatial Regulation of Lck Activation at the Immune Synapse Revealed by a FRET-Based Biosensor
2025Open Access
Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
Frontiers in Immunology·2025· 23 citedOpen Access
Treatment patterns in prostate cancer patients who received darolutamide in the ARAMIS trial in Spain: PARASEC study.
Journal of Clinical Oncology·2025
Radium-223 for mCRPC, a real-world experience study from 7 Galician medical centers.
Journal of Clinical Oncology·2023· 1 cited
Altered Surface Expression of Insulin-Degrading Enzyme on Monocytes and Lymphocytes from COVID-19 Patients Both at Diagnosis and after Hospital Discharge
International Journal of Molecular Sciences·2022· 2 citedOpen Access
Phosphorylation of cPLA2α at Ser505 Is Necessary for Its Translocation to PtdInsP2-Enriched Membranes
Molecules·2022· 5 citedOpen Access
PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders
Cellular and Molecular Life Sciences·2022· 14 citedOpen Access
Lipin-1-derived diacylglycerol activates intracellular TRPC3 which is critical for inflammatory signaling
Cellular and Molecular Life Sciences·2021· 17 citedOpen Access
Intracellular pools of DAG-activated TRPC3 channels are essential for TLR4 activation
2021Open Access
Lck bound to coreceptor is less active than free Lck
Proceedings of the National Academy of Sciences·2020· 50 citedOpen Access
Regulation of Phagocytosis in Macrophages by Membrane Ethanolamine Plasmalogens
Frontiers in Immunology·2018· 84 citedOpen Access
Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor
Nature Communications·2014· 86 citedOpen Access
Protein kinase C-η controls CTLA-4–mediated regulatory T cell function
Nature Immunology·2014· 134 citedOpen Access
Themis sets the signal threshold for positive and negative selection in T-cell development
Nature·2013· 115 citedOpen Access
Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC
The Journal of Experimental Medicine·2013· 31 citedOpen Access
Initiation of TCR phosphorylation and signal transduction. (P5041)
The Journal of Immunology·2013
Initiation of TCR Phosphorylation and Signal Transduction. (106.50)
The Journal of Immunology·2012
Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation
Science Signaling·2011· 57 citedOpen Access
Wallenberg’s syndrome and symptomatic trigeminal neuralgia
The Journal of Headache and Pain·2011· 32 citedOpen Access
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Frequent Co-authors

Jesús Balsinde(14), Marı́a A. Balboa(13), Nicholas R. J. Gascoigne(9), Joanna Brzostek(7), John A. H. Hoerter(6), Guo Fu(5), Vasily Rybakin(4), Jeanette Ampudia(4), Clara Meana(4), Miquel Barceló-Torns(3), David Barneda(3), Roser Masgrau(3), Fernando Picatoste(3), Enrique Claro(3), Mariano Sánchez Crespo(3), Stéphanie Rigaud(2), Florence Lambolez(2), Hilde Cheroutre(2), Karsten Sauer(2), Albert Gubern(2)