Mark L. Smythe

Research Institute for Bioscience and Biotechnology — NP

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index6.9kcitations77works3.32yr avg
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Research Topics

Chemical Synthesis and Analysis(38), Click Chemistry and Applications(20), Monoclonal and Polyclonal Antibodies Research(16), Protein Structure and Dynamics(7), Biochemical and Structural Characterization(6)

Publications76 total

Modulation of complement-mediated inflammation in the mdx mouse model of duchenne muscular dystrophy by PK007
Immunobiology·2025· 1 citedOpen Access
Pharmacology and macrophage modulation of HPGDS inhibitor PK007 demonstrate reduced disease severity in DMD-affected muscles of the mdx mouse model
Skeletal Muscle·2025Open Access
Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma
Nature Communications·2024· 3 citedOpen Access
Prostaglandins in the Inflamed Central Nervous System: Potential Therapeutic Targets
Current Drug Targets·2024· 9 citedOpen Access
Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction
European Heart Journal·2023· 10 citedOpen Access
Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma
2023· 1 citedOpen Access
Prostaglandins in the Inflamed Central Nervous System: Potential Therapeutic Targets
SSRN Electronic Journal·2023Open Access
Hematopoietic Prostaglandin D Synthase Inhibitor PK007 Decreases Muscle Necrosis in DMD mdx Model Mice
Life·2021· 7 citedOpen Access
The Design and synthesis of protein mimics
Figshare·2021Open Access
Hepcidin Peptidomimetics - Oral Efficacy in Pre-Clinical Disease Model of Iron Overload
Blood·2020· 4 cited
PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN- <b>λ</b> production
Science Translational Medicine·2018· 62 cited
Hepcidin Mimetic Ptg-300 for Treatment of Ineffective Erythropoiesis and Iron Overload
Queensland's institutional digital repository (The University of Queensland)·2017· 3 cited
Orally Delivered Peptides for Treatment of Inflammatory Bowel Disease
Elsevier eBooks·2016· 3 cited
Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23
BMC Bioinformatics·2016· 12 citedOpen Access
Additional file 2: of Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23
Figshare·2016Open Access
Additional file 1: of Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23
Figshare·2016Open Access
Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo
PLoS ONE·2015· 42 citedOpen Access
171
Cytokine·2014
Sigma-class glutathione transferases
Drug Metabolism Reviews·2011· 66 cited
Conformational searching using a population‐based incremental learning algorithm
Journal of Computational Chemistry·2011· 8 cited
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Frequent Co-authors

Gregory T. Bourne(23), Wim Meutermans(11), Douglas A. Horton(9), Tran T. Tran(8), Garland R. Marshall(7), Simon W. Golding(5), Paul F. Alewood(5), Jack U. Flanagan(3), Christina Kulis(3), Ashok Bhandari(3), Jaimee McMahon(3), Mark von Itzstein(2), Paul J. Brindley(2), Bernd H. Kalinna(2), Joanna Y.M. Wong(2), Donald P. McManus(2), Darryn Bryant(2), Les P. Miranda(2), Marc R. Campitelli(2), M.J. Scanlon(2)