Yongyuth Yuthavong

National Science and Technology Development Agency — Thailand

Medicine · Health Sciences

44h-index7.1kcitations263works0.42yr avg
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Research Topics

Malaria Research and Control(111), HIV/AIDS drug development and treatment(72), Biochemical and Molecular Research(48), Mosquito-borne diseases and control(27), Computational Drug Discovery Methods(22)

Publications263 total

Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors
Bioorganic Chemistry·2024
folA thyA knockout E. coli as a suitable surrogate model for evaluation of antifolate sensitivity against PfDHFR-TS
Acta Tropica·2024· 2 cited
Fola Thya Knockout E. Coli as a Suitable Surrogate Model for Evaluation of Antifolate Sensitivity Against Pfdhfr-Ts
SSRN Electronic Journal·2024Open Access
Novel flexible biphenyl <i>Pf</i>DHFR inhibitors with improved antimalarial activity
RSC Medicinal Chemistry·2024Open Access
Flexible 2,4-Diaminopyrimidine Bearing a Butyrolactone as Plasmodium Falciparum Dihydrofolate Reductase Inhibitors
SSRN Electronic Journal·2024Open Access
Development of a Practical Synthetic Method for Clinical Candidate 3-(2-{3-[(2,4-Diamino-6-ethylpyrimidin-5-yl)oxy]propoxy} phenyl)propanoic acid (P218) and Its Hydroxylated Metabolites
Synthesis·2023· 1 citedOpen Access
Susceptibility of Southeast Asian Plasmodium falciparum isolates to P218
International Journal of Antimicrobial Agents·2023· 1 citedOpen Access
Discovery of rigid biphenyl <i>Plasmodium falciparum</i> DHFR inhibitors using a fragment linking strategy
RSC Medicinal Chemistry·2023· 9 citedOpen Access
Molecular Docking Studies, Synthesis and Biological Evaluation of Substituted Pyrimidine‐2,4‐diamines as Inhibitors of <i>Plasmodium falciparum</i> Dihydrofolate Reductase
ChemMedChem·2022· 6 citedOpen Access
Key interactions of pyrimethamine derivatives specific to wild-type and mutant <i>P. falciparum</i> dihydrofolate reductase based on 3D-QSAR, MD simulations and quantum chemical calculations
Journal of Biomolecular Structure and Dynamics·2022· 1 cited
Structural Insight into Effective Inhibitors’ Binding to <i>Toxoplasma gondii</i> Dihydrofolate Reductase Thymidylate Synthase
ACS Chemical Biology·2022· 7 cited
Assay Development and Identification of the First Plasmodium falciparum 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Inhibitors
Molecules·2022· 1 citedOpen Access
Meeting malaria elimination targets and remaining challenges: Qualitative research on perceptions of stakeholders in India and Southeast Asia
Asia & the Pacific Policy Studies·2022· 3 citedOpen Access
New Insights into Antimalarial Chemopreventive Activity of Antifolates
Antimicrobial Agents and Chemotherapy·2021· 14 citedOpen Access
CCDC 2106318: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
New insights into antimalarial chemopreventive activity of antifolates
2021· 1 citedOpen Access
Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with methotrexate (MTX), NADPH and dUMP
2021
Transgenic pyrimethamine-resistant plasmodium falciparum reveals transmission-blocking potency of P218, a novel antifolate candidate drug
International Journal for Parasitology·2021· 13 cited
Scalable synthesis of favipiravir <i>via</i> conventional and continuous flow chemistry
RSC Advances·2021· 7 citedOpen Access
Discovery of new non-pyrimidine scaffolds as <i>Plasmodium falciparum</i> DHFR inhibitors by fragment-based screening
Journal of Enzyme Inhibition and Medicinal Chemistry·2021· 13 citedOpen Access
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Frequent Co-authors

Sumalee Kamchonwongpaisan(22), Worachart Sirawaraporn(14), P. Chitnumsub(10), Jarunee Vanichtanankul(9), Bongkoch Tarnchompoo(9), Yodhathai Thebtaranonth(9), Tirayut Vilaivan(8), Gordon Lowe(5), Ubolsree Leartsakulpanich(5), Jirundon Yuvaniyama(4), Rachada Sirawaraporn(4), Malcolm D. Walkinshaw(3), Daniel V. Santi(3), Supannee Taweechai(3), Rachel Quarrell(3), Phisit Prapunwattana(3), Palangpon Kongsaeree(3), Susan A. Charman(2), Chairat Uthaipibull(2), Chayaphat Wongsombat(2)