Gerald Brosch

Innsbruck Medical University — Austria

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index5.1kcitations80works0.02yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(52), Protein Degradation and Inhibitors(21), Epigenetics and DNA Methylation(17), Peptidase Inhibition and Analysis(15), Cancer-related gene regulation(11)

Publications80 total

A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation
PLoS Genetics·2022· 37 citedOpen Access
Novel Pyridine‐Based Hydroxamates and 2′‐Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity
ChemMedChem·2020· 17 citedOpen Access
RcLS2F – A Novel Fungal Class 1 KDAC Co-repressor Complex in Aspergillus nidulans
Frontiers in Microbiology·2020· 10 citedOpen Access
Type I and II PRMTs regulate catabolic as well as detoxifying processes in Aspergillus nidulans
Fungal Genetics and Biology·2019· 8 citedOpen Access
Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus <em>Aspergillus nidulans</em> for Enzymatic Activity Assay
Journal of Visualized Experiments·2019
Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus <em>Aspergillus nidulans</em> for Enzymatic Activity Assay
Journal of Visualized Experiments·2019· 5 citedOpen Access
A Class 1 Histone Deacetylase as Major Regulator of Secondary Metabolite Production in Aspergillus nidulans
Frontiers in Microbiology·2018· 51 citedOpen Access
A Class 1 Histone Deacetylase with Potential as an Antifungal Target
mBio·2016· 48 citedOpen Access
2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity
PLoS ONE·2015· 11 citedOpen Access
AmcA—a putative mitochondrial ornithine transporter supporting fungal siderophore biosynthesis
Frontiers in Microbiology·2015· 17 citedOpen Access
1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells
Journal of Medicinal Chemistry·2014· 131 citedOpen Access
A single allele of <i>Hdac2</i> but not <i>Hdac1</i> is sufficient for normal mouse brain development in the absence of its paralog
Development·2014· 88 citedOpen Access
Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis
The EMBO Journal·2013· 68 citedOpen Access
Novel Cinnamyl Hydroxyamides and 2‐Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity
ChemMedChem·2011· 19 citedOpen Access
Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulans
Fungal Genetics and Biology·2010· 24 cited
Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI‐1)
ChemMedChem·2010· 67 cited
A Novel Motif in Fungal Class 1 Histone Deacetylases Is Essential for Growth and Development of<i>Aspergillus</i>
Molecular Biology of the Cell·2009· 66 citedOpen Access
New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations
The International Journal of Biochemistry & Cell Biology·2008· 25 cited
Epigenetic Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors
Journal of Medicinal Chemistry·2008· 132 citedOpen Access
Histone modifications and chromatin dynamics: a focus on filamentous fungi
FEMS Microbiology Reviews·2008· 167 citedOpen Access
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Frequent Co-authors

Peter Loidl(30), Antonello Mai(16), Silvio Massa(11), Rino Ragno(10), Stefan Graessle(9), Ingo Bauer(8), Patrick Trojer(7), Alexandra Lusser(6), Silvia Simeoni(6), Dante Rotili(6), Manfred Jung(6), Gianluca Sbardella(6), Christian Seiser(5), Hubertus Haas(5), Angela Nebbioso(5), Lucia Altucci(5), Sérgio Valente(5), Jonathan D. Walton(4), Thomas Lechner(4), Roberto Scatena(4)