Rajiv Panwar

Medicine · Health Sciences

9h-index145citations24works0.02yr avg
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Research Topics

Radiopharmaceutical Chemistry and Applications(7), Hematopoietic Stem Cell Transplantation(6), Nanoparticle-Based Drug Delivery(4), Chemotherapy-induced cardiotoxicity and mitigation(4), Toxin Mechanisms and Immunotoxins(4)

Publications24 total

Preclinical Pharmacokinetics and Pharmacodynamics of DISC-0998, a Humanized Anti-Hemojuvelin (HJV) Monoclonal Antibody to Suppress the Production of Hepcidin
Blood·2022
DISC-0974, an Anti-Hemojuvelin Antibody, Reduces Hepcidin and Mobilizes Iron in Healthy Volunteers
Blood·2022· 1 cited
A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window across Species
Biology of Blood and Marrow Transplantation·2020· 1 cited
A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates
Biology of Blood and Marrow Transplantation·2020· 2 citedOpen Access
A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates
Blood·2019· 17 cited
Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models
Biology of Blood and Marrow Transplantation·2019· 3 citedOpen Access
Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells
Biology of Blood and Marrow Transplantation·2019· 2 citedOpen Access
Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models
Biology of Blood and Marrow Transplantation·2019· 1 citedOpen Access
A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant
Biology of Blood and Marrow Transplantation·2019· 9 citedOpen Access
CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant
Blood·2018· 11 cited
Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning
Blood·2018· 2 cited
Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models
Blood·2018
A Non-Genotoxic Antibody Drug Conjugate Targeting C-Kit for Hematopoietic Stem Cell Transplant Conditioning
Biology of Blood and Marrow Transplantation·2018· 4 citedOpen Access
Imaging doxorubicin and polymer-drug conjugates of doxorubicin-induced cardiotoxicity with bispecific anti-myosin-anti-DTPA antibody and Tc-99m-labeled polymers
Journal of Nuclear Cardiology·2018· 6 cited
Bispecific antibody complex pre-targeting and targeted delivery of polymer drug conjugates for imaging and therapy in dual human mammary cancer xenografts
European Journal of Nuclear Medicine and Molecular Imaging·2014· 24 cited
<i>In vitro</i>demonstration of enhanced prostate cancer toxicity: pretargeting with Bombesin bispecific complexes and targeting with polymer-drug-conjugates
Journal of drug targeting·2013· 9 cited
Imaging with bispecific antimyosin Fab-anti-DTPA Fab and Tc-99m polymers to demonstrate reduction of doxorubicin cardiotoxicity using polymer-drug conjugates
2012
Imaging small human prostate cancer xenografts after pretargeting with bispecific bombesin-antibody complexes and targeting with high specific radioactivity labeled polymer-drug conjugates
European Journal of Nuclear Medicine and Molecular Imaging·2012· 18 cited
Bispecific antibody complex pre-targeted delivery of polymer–drug conjugates for cancer therapy
Drug Delivery and Translational Research·2012· 15 cited
Reduction of the cardiotoxicity of Doxorubicin: Demonstration by in vivo imaging with Bispecific antibody/radiolabeled negatively charged polymers
2012
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Frequent Co-authors

Sean M. McDonough(11), Jennifer Proctor(11), Rahul Palchaudhuri(11), Anthony E. Boitano(11), Ganapathy N. Sarma(10), Lena Kien(10), Junia Dushime(10), Sharon L. Hyzy(10), Charlotte F. McDonagh(10), Bradley R. Pearse(9), Melissa Brooks(9), Keyur Gada(8), Vishwesh Patil(8), Hillary L. Adams(8), Ban‐An Khaw(7), Stan Majewski(7), Michael P. Cooke(7), Pranoti Sawant(6), Andrew D Gabros(5), Sharon Aslanian(5)