Insup Choi

Allen Institute for Brain Science — United States

Neuroscience · Life Sciences

19h-index1.8kcitations27works22.72yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(11), Parkinson's Disease Mechanisms and Treatments(10), Autophagy in Disease and Therapy(9), Nuclear Receptors and Signaling(6), RNA regulation and disease(4)

Publications27 total

RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes
Nature Communications·2024· 12 citedOpen Access
RAB12-LRRK2 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in Astrocytes
2024· 2 citedOpen Access
Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s disease
Science Advances·2024· 54 citedOpen Access
Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence
Nature Cell Biology·2023· 174 citedOpen Access
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy
Science Advances·2022· 50 citedOpen Access
Single-cell transcriptomic atlas of the human substantia nigra in Parkinson’s disease
2022· 23 citedOpen Access
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth
Proceedings of the National Academy of Sciences·2021· 55 citedOpen Access
Region-specific astrogliosis: differential vessel formation contributes to different patterns of astrogliosis in the cortex and striatum
Molecular Brain·2020· 12 citedOpen Access
Progress in LRRK2-Associated Parkinson’s Disease Animal Models
Frontiers in Neuroscience·2020· 47 citedOpen Access
Synucleinphagy: a microglial “community cleanup program” for neuroprotection
Autophagy·2020· 24 citedOpen Access
Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice
Human Molecular Genetics·2020· 48 citedOpen Access
Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
Nature Communications·2020· 510 citedOpen Access
Microglia Clear Neuron-released α-Synuclein via Selective Autophagy and Prevent Neurodegeneration
2019· 17 citedOpen Access
Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice
Molecular Neurodegeneration·2019· 95 citedOpen Access
The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease
Nature Communications·2019· 145 citedOpen Access
MOESM1 of Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice
Figshare·2019Open Access
LRRK2 Inhibits FAK Activity by Promoting FERM-mediated Autoinhibition of FAK and Recruiting the Tyrosine Phosphatase, SHP-2
Experimental Neurobiology·2016· 5 citedOpen Access
Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy
PLoS ONE·2016· 45 citedOpen Access
PINK1 Deficiency Decreases Expression Levels of mir-326, mir-330, and mir-3099 during Brain Development and Neural Stem Cell Differentiation
Experimental Neurobiology·2016· 40 citedOpen Access
Erratum to: PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAPpositive astrocytes
Molecular Brain·2016· 1 citedOpen Access
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Frequent Co-authors

Zhenyu Yue(15), Ilo Jou(9), Yuanxi Zhang(8), Qian Wang(8), Bin Zhang(7), Eun-Hye Joe(6), Steven P. Seegobin(5), Xianting Li(5), Eun-hye Joe(5), Minghui Wang(4), Beomsue Kim(4), Dong‐Joo Choi(4), Kerry Purtell(3), Junmin Peng(3), Sang Myun Park(3), Jiahong Lu(3), Hey‐Kyeong Jeong(3), Hai‐Jie Yang(3), Joo Hong Woo(3), Mathilde Pruvost(2)