Kade D. Roberts

Discovery Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index3.0kcitations66works2.32yr avg
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Research Topics

Antibiotic Resistance in Bacteria(42), Antibiotics Pharmacokinetics and Efficacy(18), Antimicrobial Peptides and Activities(17), Chemical Synthesis and Analysis(11), Pneumocystis jirovecii pneumonia detection and treatment(9)

Publications66 total

Structure–Activity Relationship of the Diaminobutyric Acid Residues in Polymyxins
JACS Au·2025Open Access
Exploring Structure–Activity Relationships and Modes of Action of Laterocidine
ACS Central Science·2024· 3 citedOpen Access
Advancing Nitrile‐Aminothiol Strategy for Dual and Sequential Bioconjugation
Chemistry - A European Journal·2024· 4 citedOpen Access
Structure–Interaction Relationship of Polymyxins with Lung Surfactant
Journal of Medicinal Chemistry·2023· 7 citedOpen Access
Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells
Antibiotics·2023· 2 citedOpen Access
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity
Journal of Medicinal Chemistry·2023· 13 cited
616. Pharmacodynamics (PD) of the lipopeptide QPX9003 Against <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> in the Neutropenic Mouse Thigh Infection Model
Open Forum Infectious Diseases·2022· 1 citedOpen Access
An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptides against Multidrug-Resistant <i>Pseudomonas aeruginosa</i>
Journal of Medicinal Chemistry·2022· 14 cited
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
Nature Communications·2022· 143 citedOpen Access
An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates
Frontiers in Chemistry·2022· 19 citedOpen Access
Synchrotron-Based X-Ray Fluorescence Microscopy Reveals Accumulation of Polymyxins in Single Human Alveolar Epithelial Cells
Antimicrobial Agents and Chemotherapy·2021· 6 citedOpen Access
A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening <i>Acinetobacter baumannii</i>
Chemical Science·2021· 18 citedOpen Access
Simulations of octapeptin–outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency
Journal of Biological Chemistry·2020· 17 citedOpen Access
Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane of <i>Acinetobacter baumannii</i>
Journal of Antimicrobial Chemotherapy·2020· 47 citedOpen Access
Structure–Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells
ACS Infectious Diseases·2020· 27 citedOpen Access
707. QPX9003: Pharmacology of a Novel Polymyxin in Mice and Rats
Open Forum Infectious Diseases·2019· 4 citedOpen Access
Discovery of Novel Polymyxin-Like Antibiotics
Advances in experimental medicine and biology·2019· 39 cited
History, Chemistry and Antibacterial Spectrum
Advances in experimental medicine and biology·2019· 37 cited
Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis <i>Pseudomonas aeruginosa</i> Isolates and Their Interactions with Sputum Biomolecules
ACS Infectious Diseases·2018· 21 citedOpen Access
Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria
Cell chemical biology·2018· 80 citedOpen Access
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Frequent Co-authors

Tony Velkov(37), Jian Li(33), Philip E. Thompson(29), Roger L. Nation(21), Mohammad Abul Kalam Azad(13), Mei‐Ling Han(7), Nitin A. Patil(7), Yan Zhu(6), Heidi H. Yu(6), John N. Lambert(5), Sivashangarie Sivanesan(5), Jiping Wang(5), Xukai Jiang(5), Gavin E. Reid(5), Lushan Wang(5), Matthew A. Cooper(4), Kai Yang(4), Bing Yuan(4), Bin Gong(4), Falk Schreiber(4)