Hideaki Tojo

Protein Research Foundation — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index2.5kcitations188works3.02yr avg
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Research Topics

Animal Genetics and Reproduction(48), Reproductive Biology and Fertility(28), Atrial Fibrillation Management and Outcomes(14), CRISPR and Genetic Engineering(14), Cardiac Arrhythmias and Treatments(14)

Publications188 total

Engineered DPP4 decoy confers broad-spectrum inhibition of MERS-CoV infection
Cell Biomaterials·2025· 3 citedOpen Access
Synthesis and evaluation of hedgehog signaling inhibitor with novel core system
Bioorganic & Medicinal Chemistry·2015· 6 cited
CCDC 1027990: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1027998: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
CCDC 1028036: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Current Status and Prospects for Exploitation of the Genetically Modified Pigs for Xenograft
2015
心肺停止を経験し,蘇生し,治癒した原発性アルドステロン症の症例
2014
A case of primary aldosteronism who experienced cardiopulmonary arrest, was resuscitated and cured
Journal of Cardiology Cases·2013· 3 citedOpen Access
TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling
International Journal of Cancer·2013· 49 citedOpen Access
Abstract 4952: A novel smoothened antagonist, TAK-441, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.
Cancer Research·2013
325 TAK-441, A NOVEL INVESTIGATIONAL SMOOTHENED ANTAGONIST, DELAYS CASTRATION RESISTANT PROGRESSION IN PROSTATE CANCER BY DISRUPTING PARACRINE HEDGEHOG SIGNALING
The Journal of Urology·2013· 2 cited
Chymase Inhibition and Cardiovascular Protection
Cardiovascular Drugs and Therapy·2013· 14 cited
Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice
Drug Metabolism and Disposition·2013· 19 cited
Differential Action of Four Long Acting Calcium Channel Blockers on Heart Rate and Renal Function
Therapeutic research·2013
CCDC 865214: Experimental Crystal Structure Determination
The Cambridge Structural Database·2013Open Access
602 INCREASED CHYMASE DEPENDENT ANGIOTENSIN II-FORMING ACTIVITY IN THE CIRCULATING MONONUCLEAR LEUKOCYTE ASSOCIATED WITH ATRIAL FIBRILLATION AND CARDIAC REMODELING
Journal of Hypertension·2012
Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors
Bioorganic & Medicinal Chemistry·2012· 64 citedOpen Access
Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
Bioorganic & Medicinal Chemistry·2012· 71 citedOpen Access
WITHDRAWN: Erratum to: “Improvements of mean body mass index and body weight in preobese and overweight Japanese adults with black Chinese tea (Pu-Erh) water extract” [Nutr Res (2011). vol. 31, pp 421-428]
Nutrition Research·2012
Identification of Whey Acidic Protein (WAP) in Dog Milk
EXPERIMENTAL ANIMALS·2012· 8 citedOpen Access
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Frequent Co-authors

Kunihiko Naito(20), Keitaro Yamanouchi(14), Chikashi Tachi(10), Koji Sugiura(8), Naoki Iwamori(6), Motoharu Seiki(4), Koichiro Kumagai(4), Tomoo Yasuda(4), Hiroo Noguchi(4), Keijiro Saku(4), Satoshi Ohashi(4), Michio Takahashi(4), Naoko Nukumi(4), Tokuko Iwamori(4), Hideko Nakashima(3), Tsutomu Endo(3), Sachio Shibata(3), Harumi Hattori(3), Maki Miyamoto(3), Haruna Naruoka(3)