Kristie A. Faust

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index524citations16works0.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(10), Renin-Angiotensin System Studies(6), Quinazolinone synthesis and applications(6), Synthesis and Biological Evaluation(6), Synthesis and Catalytic Reactions(3)

Publications16 total

The SAR of 6-(N-alkyl-N-acyl)-2-propyl-3-[(2′-tetrazol-5-yl)biphen-4-yl)methyl]-quinazolinones as balanced affinity antagonists of the human AT1 and AT2 receptors
Bioorganic & Medicinal Chemistry Letters·1995· 20 cited
ChemInform Abstract: AT1 Selective Angiotensin II Antagonists with Phenoxyphenylacetic Acid as a Biphenyl Replacement. Part 1.
ChemInform·1995
α-Phenoxyphenylacetic acid derived angiotensin II antagonists with low nanomolar AT1/AT2 receptor subtype affinity (Part II)
Bioorganic & Medicinal Chemistry Letters·1995· 6 cited
AT1 selective angiotensin II antagonists with phenoxyphenylacetic acid as a biphenyl replacement part I
Bioorganic & Medicinal Chemistry Letters·1995· 10 cited
A Highly Potent, Orally Active Imidazo[4,5-b]pyridine Biphenyl Acylsulfonamide (MK-996; L-159,282): A New AT1-Selective Angiotensin II Receptor Antagonist
Journal of Medicinal Chemistry·1994· 53 citedOpen Access
Development of angiotensin II antagonists with equipotent affinity for human AT1 and AT2 receptor subtypes.
Bioorganic & Medicinal Chemistry Letters·1994· 7 cited
In vitro phamacology of MK‐996, a new potent and selective angiotensin II (AT<sub>1</sub>) receptor antagonist
Drug Development Research·1994· 19 cited
ChemInform Abstract: Nonpeptide Angiotensin II Antagonists Derived from 1H‐Pyrazole‐5‐ carboxylates and 4‐Aryl‐1H‐imidazole‐5‐carboxylates.
ChemInform·1994· 2 cited
Triazolinones as nonpeptide angiotensin II antagonists. 2. discovery of a potent and orally active triazolinone acylsulfonamide
Bioorganic & Medicinal Chemistry Letters·1994· 11 cited
Potent imidazole angiotensinII antagonists: acyl sulfonamides and acyl sulfamides as tetrazole replacements
Bioorganic & Medicinal Chemistry Letters·1994· 29 cited
A new class of balanced AT1/AT2 angiotensin II antagonists: quinazolinone AII antagonists with acylsulfonamide and sulfonylcarbamate acidic functionalities
Bioorganic & Medicinal Chemistry Letters·1994· 23 cited
Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones
Journal of Medicinal Chemistry·1993· 28 citedOpen Access
Quinazolinones 1: design and synthesis of potent quinazolinone- containing AT1-selective angiotensin-II receptor antagonists
Bioorganic & Medicinal Chemistry Letters·1993· 20 cited
Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles
Journal of Medicinal Chemistry·1993· 52 citedOpen Access
Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists
Journal of Medicinal Chemistry·1991· 161 citedOpen Access
Two angiotensin II binding sites in rat brain revealed using [125I]Sar1, Ile8-angiotensin II and selective nonpeptide antagonists
Biochemical and Biophysical Research Communications·1990· 83 cited

Frequent Co-authors

Raymond S.L. Chang(16), Victor J. Lotti(16), Peter K. S. Siegl(10), Salah D. Kivlighn(10), Gloria J. Zingaro(9), William J. Greenlee(8), Tsing‐Bau Chen(7), Arthur A. Patchett(6), Prasun K. Chakravarty(4), Terry W. Schorn(4), Elizabeth M. Naylor(4), Wallace T. Ashton(4), Stephen E. de Laszlo(4), Linda Chang(3), Kenneth J. Fitch(3), Thomas F. Walsh(3), W. J. GREENLEE(3), Steven M. Hutchins(2), Malcolm MacCoss(2), Kelly L. Flanagan(2)