David Keeney

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index2.0kcitations29works4.02yr avg
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Research Topics

Antibiotic Resistance in Bacteria(15), Pharmaceutical and Antibiotic Environmental Impacts(6), Bacterial Genetics and Biotechnology(4), Escherichia coli research studies(4), Antibiotics Pharmacokinetics and Efficacy(4)

Publications29 total

Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine
PLoS Pathogens·2025· 7 citedOpen Access
Structure-Based Design of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine
2024· 1 citedOpen Access
Preclinical validation of an <i>Escherichia coli</i> O-antigen glycoconjugate for the prevention of serotype O1 invasive disease
Microbiology Spectrum·2024· 4 citedOpen Access
Preclinical Immunogenicity and Efficacy of Optimized O25b O-Antigen Glycoconjugates To Prevent MDR ST131 E. coli Infections
Infection and Immunity·2022· 22 citedOpen Access
Demonstration of the preclinical correlate of protection for Staphylococcus aureus clumping factor A in a murine model of infection
Vaccine·2015· 41 citedOpen Access
Characterization and Sequence Analysis of Extended-Spectrum-β-Lactamase-Encoding Genes from <i>Escherichia coli, Klebsiella pneumoniae</i> , and <i>Proteus mirabilis</i> Isolates Collected during Tigecycline Phase 3 Clinical Trials
Antimicrobial Agents and Chemotherapy·2008· 61 citedOpen Access
Microbial Fouling of a Reverse Osmosis Municipal Water Treatment System
Water Environment Research·2008· 2 citedOpen Access
MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli
Journal of Antimicrobial Chemotherapy·2007· 154 cited
AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus–Acinetobacter baumannii complex
Journal of Antimicrobial Chemotherapy·2007· 238 cited
RamA, a Transcriptional Regulator, and AcrAB, an RND-Type Efflux Pump, are Associated with Decreased Susceptibility to Tigecycline in <i>Enterobacter cloacae</i>
Microbial Drug Resistance·2007· 106 cited
Mixed Pollutant Degradation by <i>Methylosinus trichosporium</i> OB3b Expressing either Soluble or Particulate Methane Monooxygenase: Can the Tortoise Beat the Hare?
Applied and Environmental Microbiology·2006· 99 citedOpen Access
Pyrazolidine-3,5-diones and 5-Hydroxy-1<i>H</i>-pyrazol-3(2<i>H</i>)-ones, Inhibitors of UDP-<i>N</i>-acetylenolpyruvyl Glucosamine Reductase
Journal of Medicinal Chemistry·2006· 98 citedOpen Access
3,5-Dioxopyrazolidines, Novel Inhibitors of UDP- <i>N</i> - Acetylenolpyruvylglucosamine Reductase (MurB) with Activity against Gram-Positive Bacteria
Antimicrobial Agents and Chemotherapy·2006· 75 citedOpen Access
Concordant copy number and transcriptional activity of genes mapping to derivative chromosomes 8 during cellular immortalization in vitro
Genes Chromosomes and Cancer·2005· 17 cited
Pulvinones as bacterial cell wall biosynthesis inhibitors
Bioorganic & Medicinal Chemistry Letters·2005· 65 citedOpen Access
Degradation of Trafficking-defective Long QT Syndrome Type II Mutant Channels by the Ubiquitin-Proteasome Pathway
Journal of Biological Chemistry·2005· 114 citedOpen Access
Influence of Transcriptional Activator RamA on Expression of Multidrug Efflux Pump AcrAB and Tigecycline Susceptibility in <i>Klebsiella pneumoniae</i>
Antimicrobial Agents and Chemotherapy·2005· 204 citedOpen Access
AcrAB Efflux Pump Plays a Role in Decreased Susceptibility to Tigecycline in <i>Morganella morganii</i>
Antimicrobial Agents and Chemotherapy·2005· 93 citedOpen Access
Letter to the Editor: 1H, 13C, and 15N Backbone Assignments and Secondary Structure for the 60.8 kD Dimer of the NAD+ Synthetase from Bacillus Subtilis
Journal of Biomolecular NMR·2004· 1 cited
1H, 13C, and 15N backbone assignments for the 60.8 kD dimer of the NAD+ synthetase from Bacillus subtilis
Journal of Back and Musculoskeletal Rehabilitation·2004Open Access
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Frequent Co-authors

Alexey Ruzin(6), Patricia A. Bradford(6), Youjun Yang(5), Annaliesa S. Anderson(5), Anatoly Severin(4), Beth A. Rasmussen(4), Laurent Chorro(4), Srinivas Kodali(4), Arthur Illenberger(4), Robert G. K. Donald(4), B A Rasmussen(3), Guy Singh(3), William Hu(3), Peter J. Petersen(3), David N. Frick(3), Yury V. Matsuka(3), Natalie C. Silmon de Monerri(3), Karen Bush(2), Steven A. Haney(2), Jeremy D. Semrau(2)