Julien Lafrance‐Vanasse

Medicine · Health Sciences

18h-index1.1kcitations41works10.72yr avg
OpenAlex↗ORCID↗Google Scholar↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Monoclonal and Polyclonal Antibodies Research(7), DNA Repair Mechanisms(5), Genomics and Chromatin Dynamics(5), Mercury impact and mitigation studies(4), Diet, Metabolism, and Disease(4)

Publications41 total

Property Enhancer – a data efficient multi-objective approach for functional antibody optimization
2025Open Access
Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier
Nature Communications·2025· 12 citedOpen Access
Lab-in-the-loop therapeutic antibody design with deep learning
2025· 20 citedOpen Access
AbDiffuser: Full-Atom Generation of in vitro Functioning Antibodies
arXiv (Cornell University)·2023· 21 citedOpen Access
Protein Discovery with Discrete Walk-Jump Sampling
arXiv (Cornell University)·2023· 4 citedOpen Access
Protein Design with Guided Discrete Diffusion
arXiv (Cornell University)·2023· 18 citedOpen Access
A Pareto-optimal compositional energy-based model for sampling and optimization of protein sequences
arXiv (Cornell University)·2022· 4 citedOpen Access
Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid
Clinical Pharmacology & Therapeutics·2022· 39 citedOpen Access
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer’s disease
Science Translational Medicine·2021· 106 citedOpen Access
An<i>in vitro</i>FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans
mAbs·2019· 61 citedOpen Access
Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O <sub>2</sub> activation
Proceedings of the National Academy of Sciences·2019· 50 citedOpen Access
Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies.
PubMed·2019· 8 cited
Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies
Bioconjugate Chemistry·2018· 24 cited
Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression
Scientific Reports·2018· 51 citedOpen Access
Formylglycine generating enzyme bound to copper
2018
Structural and Biochemical Characterization of a Copper-Binding Mutant of the Organomercurial Lyase MerB: Insight into the Key Role of the Active Site Aspartic Acid in Hg–Carbon Bond Cleavage and Metal Binding Specificity
Biochemistry·2016· 20 cited
Crystal structure of the mercury-bound form of MerB2
2015
Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair
Progress in Biophysics and Molecular Biology·2015· 107 citedOpen Access
The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once
DNA repair·2014· 88 cited
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis
Genes & Development·2014· 57 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

James G. Omichinski(13), J. Sygusch(12), Isidro Hötzel(7), James A. Ernst(6), Paola Di Lello(6), Geneviève Arseneault(6), Kyunghyun Cho(6), John A. Tainer(5), Laurent Cappadocia(5), Pascale Legault(5), Richard Bonneau(5), Vladimir Gligorijević(5), Andreas Loukas(5), M. St-Jean(4), B. Liotard(4), Nathan C. Frey(4), Jasvinder K. Atwal(3), Kristin R. Wildsmith(3), M. Lefebvre(3), Mathieu Lussier-Price(3)