Mathieu Botte

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index390citations16works0.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(8), Bacterial Genetics and Biotechnology(7), Bacteriophages and microbial interactions(4), Ion channel regulation and function(3), Protein Structure and Dynamics(2)

Publications16 total

Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses
Journal for ImmunoTherapy of Cancer·2022· 35 citedOpen Access
Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators
PNAS Nexus·2022· 19 citedOpen Access
Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
Nature Communications·2022· 54 citedOpen Access
Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators
2021· 3 citedOpen Access
Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies
2021· 2 citedOpen Access
Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation
2020· 22 citedOpen Access
Structure based drug discovery on membrane protein targets
Biochemistry & Molecular Biology Journal·2018· 1 citedOpen Access
A central cavity within the holo-translocon suggests a mechanism for membrane protein insertion
Scientific Reports·2016· 63 citedOpen Access
EM fitted model of bacterial holo-translocon
2016
leadXPro – structure-based drug design on membrane protein targets at SwissFEL
Acta Crystallographica Section A Foundations and Advances·2016Open Access
Cell-Free Synthesis of Macromolecular Complexes
Advances in experimental medicine and biology·2016Open Access
Advances and challenges of membrane–protein complex production
Current Opinion in Structural Biology·2015· 37 cited
ACEMBLing a Multiprotein Transmembrane Complex
Methods in enzymology on CD-ROM/Methods in enzymology·2015· 9 cited
The insertion and assembly of membrane proteins (including subunits of the ATP synthase) by the bacterial holo-translocon
Biochimica et Biophysica Acta (BBA) - Bioenergetics·2014
Membrane protein insertion and proton-motive-force-dependent secretion through the bacterial holo-translocon SecYEG–SecDF–YajC–YidC
Proceedings of the National Academy of Sciences·2014· 145 citedOpen Access
Architecture de l'Holotranslocon SecYEG-DF-YajC-YidC
ZooKeys·2013Open Access

Frequent Co-authors

Christiane Schaffitzel(7), Michael Hennig(7), Denis Bucher(6), R.K. Cheng(6), Ian Collinson(5), Mohamed Chami(5), Imre Berger(4), Nicolas Bocquet(4), Henning Stahlberg(3), Sophie Huber(3), Joanna Komar(2), Nathan R. Zaccai(2), Jelger Lycklama a Nijeholt(2), Rémy Martin(2), Aurélien Deniaud(2), Qiyang Jiang(2), Dongchun Ni(2), Stephan Schenck(2), Iwan Zimmermann(2), Pascal Egloff(2)