V.A. Kostyuchenko

National University of Singapore — Singapore

Medicine · Health Sciences

35h-index6.6kcitations95works6.52yr avg
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Research Topics

Mosquito-borne diseases and control(53), Bacteriophages and microbial interactions(30), Viral Infections and Vectors(27), Cytomegalovirus and herpesvirus research(13), RNA and protein synthesis mechanisms(11)

Publications95 total

An ultrapotent human antibody neutralizes all maturation states of Zika virus
Proceedings of the National Academy of Sciences·2025Open Access
Accurate and fast segmentation of filaments and membranes in micrographs and tomograms with TARDIS
2024· 13 citedOpen Access
Tomography studies of the dengue fusion process
Acta Crystallographica Section A Foundations and Advances·2023· 1 citedOpen Access
CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever
Nature Communications·2022· 66 citedOpen Access
CryoEM structures of the multimeric secreted NS1, a major factor for dengue hemorrhagic fever
2022· 7 citedOpen Access
Antibody affinity versus dengue morphology influences neutralization
PLoS Pathogens·2021· 11 citedOpen Access
Cryo-EM structure of Dengue virus serotype 1 strain WestPac 74 in complex with human antibody 1C19 Fab at 37 deg C (Class 1 particle)
2021
A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins
UNC Libraries·2020Open Access
A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface
UNC Libraries·2020· 11 citedOpen Access
Structural basis of Chikungunya virus inhibition by monoclonal antibodies
Proceedings of the National Academy of Sciences·2020· 70 citedOpen Access
Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG (subregion around icosahedral 2-fold vertex)
2020
Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG
2020
Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124
2020
High flavivirus structural plasticity demonstrated by a non-spherical morphological variant
Nature Communications·2020· 30 citedOpen Access
Helical reconstruction of Dengue virus serotype 3 complexed with Fab C10
2020
Helical reconstruction of Zika virus complexed with Fab C10
2020
Neutralization mechanism of a highly potent antibody against Zika virus
UNC Libraries·2020· 8 citedOpen Access
Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 5.0
2020
Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 6.5
2020
Cryo-EM structure of Dengue virus serotype 2 complexed with Fab SIgN-3C at pH 8.0
2020
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Frequent Co-authors

Shee‐Mei Lok(25), Michael G. Rossmann(24), Thiam‐Seng Ng(19), Paul R. Chipman(18), Vadim V. Mesyanzhinov(15), G. Fibriansah(13), P.G. Leiman(13), Jian Shi(11), Xin-Ni Lim(7), Justin S. G. Ooi(6), Shuji Kanamaru(6), Fumio Arisaka(6), Anthony J. Battisti(6), Joanne L. Tan(6), James E. Crowe(6), Lidia P. Kurochkina(6), Mikhail M. Shneider(6), Heather A. Holdaway(5), Shuijun Zhang(5), Jiaqi Wang(5)