Tomasz Skórski

Temple University — United States

Medicine · Health Sciences

54h-index9.3kcitations422works1.02yr avg
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Research Topics

Chronic Myeloid Leukemia Treatments(125), DNA Repair Mechanisms(109), Acute Myeloid Leukemia Research(87), PARP inhibition in cancer therapy(82), Chronic Lymphocytic Leukemia Research(65)

Publications422 total

Correction: Barszczewska-Pietraszek et al. Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells. Int. J. Mol. Sci. 2024, 25, 9134
International Journal of Molecular Sciences·2026Open Access
Supplementary Figure 4 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
2025Open Access
Supplementary Figure 5 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
2025Open Access
Supplementary Figure 1 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
2025Open Access
Supplementary Figure 3 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
2025Open Access
Supplementary Figure 2 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells
2025Open Access
PSF3 recruits DNA polymerase theta (Polθ) to stalled replication forks to promote DNA repair and survival of myeloid malignant cells.
Blood·2025
Targeting DNA repair vulnerabilities to eradicate TP53 mutated AML.
Blood·2025
Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer
Proceedings of the National Academy of Sciences·2025
RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors
Journal of Medicinal Chemistry·2025· 2 citedOpen Access
Selective Sensitivity of Ph-like B-ALL to BRG1 Inhibition Reveals a Novel Targeted Therapy Strategy
2025Open Access
ADH5/ALDH2 dehydrogenases and DNA polymerase theta protect normal and malignant hematopoietic cells from formaldehyde challenge: therapeutic implications
Leukemia·2025· 1 citedOpen Access
ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination
Cancer Letters·2025· 3 citedOpen Access
Clonal composition of karyotypically normal AML at diagnosis is not affected by the microenvironment
Blood Neoplasia·2025Open Access
Targeting the SWI/SNF Chromatin Remodeling Complex Subunit SMARCA4 in ALL
Blood·2024
ADH5/ALDH2 Dehydrogenases and DNA Polymerase Theta Protect Hematopoietic Cells from Formaldehyde Challenge: Therapeutic Implications
Blood·2024Open Access
DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells
2024Open Access
Data from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
2024Open Access
Supplementary Figure 5 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
2024Open Access
Supplementary Figure 2 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells
2024Open Access
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Frequent Co-authors

Margaret Nieborowska-Skorska(14), Bruno Calabretta(13), Artur Słupianek(13), Mariusz A. Wasik(11), Malgorzata Nieborowska-Skorska(8), Michal O. Nowicki(8), Mateusz Koptyra(8), Tomasz Stokłosa(7), Danilo Perrotti(6), Grażyna Hoser(6), Janusz Błasiak(5), Paolo Salomoni(5), Katherine Sullivan(5), Yashodhara Dasgupta(5), Mirosław Majewski(4), Kimberly Cramer(4), Peter Valent(4), Krzysztof Reiss(4), Stephen M. Sykes(4), Paweł Włodarski(4)