Mónika Vastag

Gedeon Richter (Hungary) — Hungary

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.4kcitations55works5.82yr avg
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Research Topics

Receptor Mechanisms and Signaling(14), Pharmacological Receptor Mechanisms and Effects(13), Barrier Structure and Function Studies(12), Neuroscience and Neuropharmacology Research(10), Drug Transport and Resistance Mechanisms(8)

Publications55 total

The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger
Journal of Medicinal Chemistry·2026Open Access
Development of dual V1a/V2 antagonists containing triazolobenzazepine scaffold
European Journal of Medicinal Chemistry·2024
Synergistic induction of blood–brain barrier properties
Proceedings of the National Academy of Sciences·2024· 22 citedOpen Access
Discovery of Novel Steroid-Based Histamine H<sub>3</sub> Receptor Antagonists/Inverse Agonists
Journal of Medicinal Chemistry·2024· 3 citedOpen Access
Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist
Journal of Medicinal Chemistry·2024· 4 citedOpen Access
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560)
Journal of Medicinal Chemistry·2023· 2 citedOpen Access
Synergistic induction of blood-brain barrier properties
2023· 2 citedOpen Access
Synergistic induction of blood-brain barrier properties
SPIRE - Sciences Po Institutional REpository·2023Open Access
Identification of Triazolopyridines as Selective α5-GABA<sub>A</sub> Receptor Negative Allosteric Modulators by a Hybridization Approach
ACS Chemical Neuroscience·2022· 4 cited
Multiparameter Optimization of Naphthyridine Derivatives as Selective α5-GABA<sub>A</sub> Receptor Negative Allosteric Modulators
Journal of Medicinal Chemistry·2022· 6 citedOpen Access
Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes
Pharmaceutics·2021· 17 citedOpen Access
Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods
Micromachines·2021· 123 citedOpen Access
Fragment-Based Optimization of Dihydropyrazino-Benzimidazolones as Metabotropic Glutamate Receptor-2 Positive Allosteric Modulators against Migraine
Journal of Medicinal Chemistry·2021· 3 citedOpen Access
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor
European Journal of Medicinal Chemistry·2021· 2 citedOpen Access
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach
European Journal of Medicinal Chemistry·2021· 15 citedOpen Access
Discovery of New Heterocyclic Ring Systems as Novel and Potent V<sub>1A</sub> Receptor Antagonists
ACS Chemical Neuroscience·2020· 6 cited
Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs)
European Journal of Medicinal Chemistry·2019· 6 citedOpen Access
Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability
Pharmaceutics·2019· 55 citedOpen Access
Comparison of a Rat Primary Cell-Based Blood-Brain Barrier Model With Epithelial and Brain Endothelial Cell Lines: Gene Expression and Drug Transport
Frontiers in Molecular Neuroscience·2018· 127 citedOpen Access
Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural Information
Journal of Medicinal Chemistry·2018· 14 citedOpen Access
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Frequent Co-authors

István Greiner(15), Sándor Kolok(14), György M. Keserű(13), Mária A. Deli(11), Éva Hellinger(10), György Domány(9), János Kóti(9), Szilvia Veszelka(8), Katalin Sághy(8), Zsolt Nagy(8), Zoltán Béni(8), Fruzsina R. Walter(7), Béla Kiss(7), Amrita Bobok(7), György Lévay(7), Imre Bata(7), Károly Tihanyi(6), Katalin Nógrádi(6), István Gyertyán(6), Zsolt Szombathelyi(6)