Sharlyn J. Mazur

National Institutes of Health — United States

Medicine · Health Sciences

29h-index3.4kcitations67works0.82yr avg
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Research Topics

Cancer-related Molecular Pathways(27), DNA Repair Mechanisms(15), Epigenetics and DNA Methylation(11), DNA and Nucleic Acid Chemistry(10), Ubiquitin and proteasome pathways(9)

Publications67 total

Exploring PPM1D Phosphatase Structure for Next-Generation Small Molecule Inhibitor Development
Structural Dynamics·2025Open Access
BPS2025 - PPM1D phosphatase: Crystal structure, mechanistic studies, and structure-based virtual screening
Biophysical Journal·2025
BPS2025 - PPM1D phosphatase: Crystal structure, mechanistic studies, and structure-based virtual screening
Biophysical Journal·2025
Crystal structure and mechanistic studies of the PPM1D serine/threonine phosphatase catalytic domain
Journal of Biological Chemistry·2024· 3 citedOpen Access
Abstract A103: Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile
Molecular Cancer Therapeutics·2023
Variation of Tetrahydrofurans in Thyclotides Enhances Oligonucleotide Binding and Cellular Uptake of Peptide Nucleic Acids
JACS Au·2023· 8 citedOpen Access
Targeting mutant p53-R248W reactivates WT p53 function and alters the onco-metabolic profile
Frontiers in Oncology·2023· 5 citedOpen Access
Alkyl-substituted N-methylaryl-N′-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase
European Journal of Medicinal Chemistry·2022Open Access
The Processing of Holliday Junctions by BLM and WRN Helicases Is Regulated by p53
UNC Libraries·2021· 15 citedOpen Access
Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses
Nature Communications·2021· 37 citedOpen Access
Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA
Nucleic Acids Research·2020· 31 citedOpen Access
An Acetyl-Methyl Switch Drives a Conformational Change in p53
UNC Libraries·2020Open Access
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens
Journal of Biological Chemistry·2019· 9 citedOpen Access
Trapped human PPM1A-phosphopeptide complex: structural implications for regulation of PPM metal- dependent protein phosphatase activity
Journal of Biological Chemistry·2018
A trapped human PPM1A–phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity
Journal of Biological Chemistry·2018· 26 citedOpen Access
Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain
ChemMedChem·2018· 10 citedOpen Access
Abstract 3867: Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy to reactivate p53 in high-risk neuroblastoma
Cancer Research·2017· 1 cited
Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange–Mass Spectrometry
Biochemistry·2017· 7 citedOpen Access
The Area Between Exchange Curves as a Measure of Conformational Differences in Hydrogen-Deuterium Exchange Mass Spectrometry Studies
Journal of the American Society for Mass Spectrometry·2017· 12 citedOpen Access
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma
Cancer Cell·2017· 123 citedOpen Access
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Frequent Co-authors

Ettore Appella(36), Lisa M. Jenkins(11), Stewart R. Durell(7), Subrata Debnath(7), Daniel H. Appella(7), Vilhelm A. Bohr(6), Harichandra D. Tagad(6), Yang Xu(4), Curtis C. Harris(4), Oleg N. Demidov(4), Victor Clausse(4), Tongxiang Lin(3), M. Thomas Record(3), Joseph E. Tropea(3), Xin Wei Wang(3), John K. Inman(3), Matteo Rossi(3), Lawrence I. Grossman(3), Anastasia R. Goloudina(3), Kan Tanoue(3)